IPLab:Lab 10:Mucormycosis

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Clinical Summary

This 63-year-old white male was in his usual state of good health until eight weeks before his death when he developed sudden onset of shortness of breathShortness of breath is a common clinical manifestation of heart failure.. A thoracotomyA thoracotomy is a surgical procedure in which an opening is made in the chest wall. was performed for plication of ruptured emphysematous blebs. Following improvement and discharge from the hospital he developed weakness, lethargy, and a left lower lobe lung infiltrateAn infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.. The patient's condition soon deteriorated further, with almost every organ system having failed. The patient developed DIC and peripheral embolic phenomena, including gangrene of his extremities and face. A single antemortem blood culture grew Staphylococcus aureus.

Autopsy Findings

Autopsy revealed severe emphysemaPulmonary emphysema is a condition in which the air spaces distal to the terminal bronchioles are permanently increased in size due to either destruction of the wall or alveolar dilatation., severe widespread abscessiform and necrotizing pneumoniaIn alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents., and bacterial (Staphylococcus aureus) endocarditis of the pulmonic valve. The right internal carotid artery was occluded by a thrombusA thrombus is a solid mass resulting from the aggregation of blood constituents within the vascular system. and there were areas of necrosis (due to CVAs) in the brain.


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