This 63-year-old white male was in his usual state of good health until eight weeks before his death when he developed sudden onset of shortness of breathShortness of breath is a common clinical manifestation of heart failure.. A thoracotomyA thoracotomy is a surgical procedure in which an opening is made in the chest wall. was performed for plication of ruptured emphysematous blebs. Following improvement and discharge from the hospital he developed weakness, lethargy, and a left lower lobe lung infiltrateAn infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.. The patient's condition soon deteriorated further, with almost every organ system having failed. The patient developed DIC and peripheral embolic phenomena, including gangrene of his extremities and face. A single antemortem blood culture grew Staphylococcus aureus.
Autopsy revealed severe emphysemaPulmonary emphysema is a condition in which the air spaces distal to the terminal bronchioles are permanently increased in size due to either destruction of the wall or alveolar dilatation., severe widespread abscessiform and necrotizing pneumoniaIn alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents., and bacterial (Staphylococcus aureus) endocarditis of the pulmonic valve. The right internal carotid artery was occluded by a thrombusA thrombus is a solid mass resulting from the aggregation of blood constituents within the vascular system. and there were areas of necrosis (due to CVAs) in the brain.
This is an even higher-power photomicrograph of the wall of the carotid artery (1) and the thrombus (2). Within the wall of the artery and in the thrombus there are multiple variably shaped clear areas (3). At this magnification and with this stain, it is impossible to determine what these clear spaces represent.
The spores are widespread in dust and air and can be inhaled or ingested. They are ubiquitous contaminants colonizing the normal human skin or gut without causing illness in immunocompetent people.
Mucor commonly causes vasculitis and thrombosis.
The three primary sites of Mucor invasion are the nasal sinuses, lungs, and gastrointestinal tract.
In diabetics, the fungus may spread from nasal sinuses to the orbit, and subsequently the brain, giving rise to rhinocerebral mucormycosis.
- Marcó del Pont J, De Cicco L, Gallo G, Llera J, De Santibanez E, D'agostino D. Hepatic arterial thrombosis due to Mucor species in a child following orthotopic liver transplantation. Transpl Infect Dis 2000 Mar;2(1):33-5.
Related IPLab Cases