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IPLab:Lab 6:Chronic Rejection

Revision as of 23:47, 8 July 2020 by Peter Anderson (talk | contribs) (Clinical Summary)

Contents

Clinical SummaryEdit

This 39-year-old male had malignant hypertension with malignant nephrosclerosis, progressing to chronic renal failure. He underwent a bilateral nephrectomy for control of his hypertension and received a cadaveric renal transplant. He did well, although his bllod pressure was elevated and his BUN and creatinine were gradually rising despite aggressive treatment. A transplant nephrectomy was performed 4 years after his transplant and he resumed hemodialysis.

The kidney weighed 125 grams and was covered by a thick capsule, which was partially adherent to the cortex, but could be stripped from the kidney with slight difficulty. The cortex was thinned but calyces and pelvis of the kidney appeared normal. The vessels were not prominent. The renal arteries and vein appeared normal.

Surgical Pathology FindingsEdit

The kidney weighed 215 grams and was covered by a thick capsule, which was partially adherent to the cortex, but could be stripped from the kidney with slight difficulty. The calyces and pelvis of the kidney appeared normal. The vessels were not prominent. The renal arteries and vein appeared normal.

ImagesEdit

Virtual MicroscopyEdit

Study QuestionsEdit


Additional ResourcesEdit

Related IPLab CasesEdit

Hypertension which has caused end-organ damage is termed malignant. Without proper treatment, these patients will usually die in less than 2 years. Blood pressures in patients with malignant hypertension are frequently 160/110 mm Hg or greater.

Renal failure is the severe reduction of renal function and often leads to reduced urinary output.

These tests are measures of kidney function. High levels mean low function.

A normal gamma-glutamyl transpeptidase (GGT) is 0 to 65 U/L.

A normal kidney weighs 157 grams (range: 115 to 220 grams).

An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.