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Cytologically Yours: Unknowns: 201311: Case 3

427 bytes added, 19:54, 10 January 2014
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==Cytology==
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CytologicallyYoursUnknowns201311-23-01.jpgCytologicallyYoursUnknowns201311-23-02.jpgCytologicallyYoursUnknowns201311-23-03.jpg
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===Resident Questions===
* <spoiler text="Diagnosis?">
* Follicular neoplasm)Papillary carcinoma. </spoiler>
* <spoiler text="What are the most common molecular associations?">
* Ras mutation in 49%Rearrangements of Ret proto-oncogene on Chromosome 10 (RET/PTC). * PAX8-PPAR gamma rearrangements in 36%Point mutations of BRAF and RAS </spoiler>* <spoiler text="What other entities of the thyroid may exhibit intranuclear pseudoinclusions?">*Medullary carcinoma.</spoiler> ==Cytologic Features==*Powdery chromatin, grooves, pseudoinclusions, nucleolus*Crowding and overlapping*Sheets, papillae*Variable cytoplasm (scant, squamoid, Hurthle-like, vacuolated)*Psammoma bodies*Giant cells*Bubble gum colloid*Septated cytoplasm