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Created page with "==Clinical History== 57 year old female with hypoechoic nodule on ultrasound. ==Cytology== <gallery heights="250px" widths="250px"> CytologicallyYoursUnknowns201311-3-01.jpg ..."
==Clinical History==
57 year old female with hypoechoic nodule on ultrasound.
==Cytology==
<gallery heights="250px" widths="250px">
CytologicallyYoursUnknowns201311-3-01.jpg
CytologicallyYoursUnknowns201311-3-02.jpg
CytologicallyYoursUnknowns201311-3-03.jpg
</gallery>
===Resident Questions===
* <spoiler text="Diagnosis?">
* Medullary carcinoma. </spoiler>
* <spoiler text="What syndrome is associated with this entity?">
* MEN 2A and MEN 2B.
* 80-90% are sporadic </spoiler>
* <spoiler text="What are the immunohistochemical features?">
* Immunoreactivity with CEA, TTF1, calcitonin, chromogranin, synaptophysin.
* Negative immunoreactivity with thyroglobulin </spoiler>
* <spoiler text="What extracellular material may be associated with this neoplasm?">
* Amyloid.</spoiler>
57 year old female with hypoechoic nodule on ultrasound.
==Cytology==
<gallery heights="250px" widths="250px">
CytologicallyYoursUnknowns201311-3-01.jpg
CytologicallyYoursUnknowns201311-3-02.jpg
CytologicallyYoursUnknowns201311-3-03.jpg
</gallery>
===Resident Questions===
* <spoiler text="Diagnosis?">
* Medullary carcinoma. </spoiler>
* <spoiler text="What syndrome is associated with this entity?">
* MEN 2A and MEN 2B.
* 80-90% are sporadic </spoiler>
* <spoiler text="What are the immunohistochemical features?">
* Immunoreactivity with CEA, TTF1, calcitonin, chromogranin, synaptophysin.
* Negative immunoreactivity with thyroglobulin </spoiler>
* <spoiler text="What extracellular material may be associated with this neoplasm?">
* Amyloid.</spoiler>
