IPLab:Lab 2:Hyperplasia

Images

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  This photograph shows the autopsy specimen from this patient. Included are kidneys (1), ureters (2), bladder (3) (which has been opened), and enlarged prostate (4). Note that the bladder mucosa has multiple trabeculae and the bladder mucosa is hyperemic. Also note that the ureters are dilated.

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  This is a close-up of the prostate from this same patient. Note the nodularity of the tissue (1) and the enlargement of the gland. Enlargement of the prostate leads to compression of the urethra as it passes through (2) the gland.

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  This is a low-power photomicrograph showing hyperplastic prostate on the left (1) and normal prostate on the right (2). At this power, dilated glands are visible in the section of hyperplastic prostate.

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  The dilated glands (arrows) make up the major portion of the prostate tissue and there is compression of the stroma.

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  Note these glands, which exhibit hyperplasia of the glandular epithelium. The infolding of the glandular epithelial cells forms papillary projections (arrows) into the lumen of the gland.

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  Cystic dilatation of glands is present in this photomicrograph. Notice the accumulation of secretory material inside the glands (arrows) and compression (thinning) of the lining epithelium.

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  A higher-power view shows the papillary folds (arrows) produced by the hyperplastic epithelium projecting into the lumen of the gland. While these papillary folds project into the lumen of the gland, there is no extension through the glandular basement membrane into the gland's stroma.

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  This is a higher-power photomicrograph of papillary folds of hyperplastic epithelium (arrows).

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  This kidney was removed from another autopsy patient who had prostatic hyperplasia resulting in marked urinary retention and back-flow of urine from the bladder into the ureters and renal pelvis. The increased pressure inside the renal pelvis resulted in dilation of the renal pelvis (1) and pressure atrophy of the cortex (2). This change in the kidney is called hydronephrosis.