Cytologically Yours: Unknowns: 201312: Case 3

Clinical History

54 year old female. Left breast 1cm nodule. FNA.

Cytology

Resident Questions

Surgical Pathology

Cytologic Features

  • Biphasic appearance: Epithelium and mesenchymal/stromal
  • Epithelium appears as cohesive monolayer sheets of well-organized epithelium with branching and papillary-like architecture (staghorn) or tubular
  • Naked bipolar myoepithelial cells in the background (rice grain appearance)
  • Variably cellular stromal fragments