Cytologically Yours: Unknowns: 201311: Case 1

Clinical History

45 year old female with hypothyroidism.

Cytology

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Resident Questions

• Diagnosis?

• Lymphocytic thyroiditis (Hashimoto thyroiditis).

What are the clinical findings that support this diagnosis?

• The diagnosis of Hashimoto is based on one or more circulating autoantibodies. The most common are anti-thyroglobulin and anti-thyroid peroxidase (TPO).

Cytologic Features

• Hurthle cells with intermingled lymphocytes.
• Often colloid is rare or absent.
• Large lymphoid aggregates with germinal centers.