IPLab:Lab 10:Histoplasmosis
Contents
Clinical SummaryEdit
For four months before death, this two-year-old black female infant ate poorly and lost weight. When hospitalized, she appeared chronically ill with signs of infection. An exploratory laparotomy showed the patient had enormously enlarged abdominal lymph nodes, the biopsy of which disclosed active histoplasmosis. Despite intensive therapy, the patient died three weeks after admission.
Autopsy FindingsEdit
Autopsy showed widespread enlargement of lymph nodes, ulcers of the intestines, and enlarged adrenal glands exhibiting multifocal granulomas.
ImagesEdit
This is an even higher-power photomicrograph of an area of necrosis (arrows). There is loss of cellular detail within this area. There are inflammatory cells present; however, it is difficult to differentiate the inflammatory cells from the native lymphocytes of the adrenal gland--which is a lymph node.
Study QuestionsEdit
Additional ResourcesEdit
ReferenceEdit
Journal ArticlesEdit
- de Pauw BE. Advances in the management of invasive fungal infections in organ transplant recipients: step by step. Transpl Infect Dis 2000 Jun;2(2):48-50.
ImagesEdit
An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.