IPLab:Lab 10:Histoplasmosis

Images

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  This low-power photomicrograph shows a section of adrenal gland with several irregularly-outlined areas of necrosis.
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  This higher-power photomicrograph of the previous adrenal gland shows more clearly the irregularly-shaped area of necrosis (arrows).
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  This is an even higher-power photomicrograph of an area of necrosis (arrows). There is loss of cellular detail within this area. There are inflammatory cells present; however, it is difficult to differentiate the inflammatory cells from the native lymphocytes of the adrenal gland--which is a lymph node.
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  This high-power photomicrograph was taken at the edge of the area of necrosis. There is a mild inflammatory infiltrate along the edge of the necrosis.
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  This high-power photomicrograph shows small (2-5 mm) dark-staining organisms in the cytoplasm of many of these cells (arrows).
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  This is a high-power photomicrograph of the same section of tissue as the previous slide. This section, however, has been stained with methenamine silver which causes the Histoplasma organisms to stain black (arrows).
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  This photomicrograph was taken under oil immersion to show the silver-stained Histoplasma organisms. Some of the organisms appear to be budding (arrows).

An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.