CRP-01: Difference between revisions
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'''CRP-01''' | |||
== Clinical History== | ==Clinical History== | ||
The patient is a 76 year old female. | The patient is a 76 year old female. | ||
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==Pathology== | ==Pathology== | ||
===Case | ===Case CRP-001 H&E=== | ||
<peir-vm>specialcrp/CRP-001_HE</peir-vm> | <peir-vm>specialcrp/CRP-001_HE</peir-vm> | ||
===Case | ===Case CRP-001 PASH=== | ||
<peir-vm>specialcrp/CRP-001_PASH</peir-vm> | <peir-vm>specialcrp/CRP-001_PASH</peir-vm> | ||
===Case | ===Case CRP-001 Silver=== | ||
<peir-vm>specialcrp/CRP-001_Silver</peir-vm> | <peir-vm>specialcrp/CRP-001_Silver</peir-vm> | ||
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==Microscopic Description:== | ==Microscopic Description:== | ||
=== | ===Light Microscopy:=== | ||
The specimen consists of two fragments of renal cortex that contain at least 36 glomeruli. Four of these are obsolete. The remaining glomeruli are all similar and show striking diffuse proliferation with accentuation of the normal lobular pattern. Many of the extra cells in the glomeruli are polymorphonuclear leukocytes. Because of the marked mesangial and endocapillary proliferation, Very few capillary loops are still patent. Silver and PASH stains show thickening of the capillary basement membranes, and examples of double contours consistent with mesangial interposition are identified with the silver stain. The trichrome stain shows reddish-orange subendothelial deposits in some of the loops, which probably represent immune complex deposits. No segmental sclerosis or necrosis is identified, and there are no epithelial crescents. There is diffuse mild interstitial fibrosis, and there is focal mild tubular atrophy. However, many of the tubules still show very good preservation. Occasional lymphocytes and plasma cells are scattered throughout the interstitium, but no large collections of inflammatory cells are present. There is no tubulitis. The small arteries in the biopsy show minimal intimal fibrosis, and there is no evidence of vasculitis. | The specimen consists of two fragments of renal cortex that contain at least 36 glomeruli. Four of these are obsolete. The remaining glomeruli are all similar and show striking diffuse proliferation with accentuation of the normal lobular pattern. Many of the extra cells in the glomeruli are polymorphonuclear leukocytes. Because of the marked mesangial and endocapillary proliferation, Very few capillary loops are still patent. Silver and PASH stains show thickening of the capillary basement membranes, and examples of double contours consistent with mesangial interposition are identified with the silver stain. The trichrome stain shows reddish-orange subendothelial deposits in some of the loops, which probably represent immune complex deposits. No segmental sclerosis or necrosis is identified, and there are no epithelial crescents. There is diffuse mild interstitial fibrosis, and there is focal mild tubular atrophy. However, many of the tubules still show very good preservation. Occasional lymphocytes and plasma cells are scattered throughout the interstitium, but no large collections of inflammatory cells are present. There is no tubulitis. The small arteries in the biopsy show minimal intimal fibrosis, and there is no evidence of vasculitis. | ||