Pathology Education Instructional Resource

IPLab:Lab 3:Brain Infarction: Difference between revisions

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File:IPLab3BrainInfarction1.jpg|This is a gross photograph of the brain which contains two areas of infarction (arrows).
File:IPLab3BrainInfarction1.jpg|This is a gross photograph of the brain which contains two areas of infarction (arrows).
File:IPLab3BrainInfarction2.jpg|This is a gross photograph of a cross-section of brain demonstrating the areas of infarction (arrows).
File:IPLab3BrainInfarction2.jpg|This is a gross photograph of a cross-section of brain demonstrating the areas of infarction (arrows).
File:IPLab3BrainInfarction3.jpg|This is a low-power photomicrograph of brain at the edge of the infarct. Note the loss of brain parenchyma (arrows).
File:IPLab3BrainInfarction3b.JPG|This is a low-power photomicrograph of this brain with several areas of infarcted tissue. Note the pale areas which correspond to areas with loss of brain parenchyma (arrows).
File:IPLab3BrainInfarction4.jpg|This is a photomicrograph of the edge of the infarct. Note the numerous inflammatory cells in the brain parenchyma and adjacent to the remaining brain tissue (arrows).
File:IPLab3BrainInfarction4b.JPG|This photomicrograph shows the area of healed/healing infarction (I) and more normal brain parenchyma (B).
File:IPLab3BrainInfarction5.jpg|This is a higher-power photomicrograph of the previous image showing that the inflammatory cells (arrows) are primarily macrophages and microglia which have phagocytosed the dead brain tissue.
File:IPLab3BrainInfarction5b.JPG|This is a higher-power photomicrograph of the previous image showing the area of healed/healing infarction (I) and more normal brain parenchyma (B). In the infarcted area contains numerous microglia (brain macrophages) that have phagocytosed dead brain cell debris that are called "gitter cells".  In the more normal brain tissue there are several enlarged astrocytes.  These activated astrocytes are often seen in areas of healing and they are called "gemistocytic astrocytes".  
File:IPLab3BrainInfarction6.jpg|This is a photomicrograph of brain tissue adjacent to the area of infarction. There are numerous activated gemistocytic astrocytes (arrows).
File:IPLab3BrainInfarction6b.JPG|This is a higher-power photomicrograph of the brain tissue adjacent to the infarct. In this image there are numerous enlarged activated astrocytes that are often seen in areas of brain healing - gemistocytic astrocytes (arrows).
File:IPLab3BrainInfarction7.jpg|This is a photomicrograph of the edge of the infarct. The macrophages that are full of brain tissue (“gitter cells”) are at the top of the image (arrows) and the brain parenchyma containing gemistocytic astrocytes is at the bottom.
File:IPLab3BrainInfarction7b.JPG|This is a higher-power photomicrograph of infarcted brain tissue with numerous macrophages (microglia) that are full of brain tissue - gitter cells (arrows).  
File:IPLab3BrainInfarction8.jpg|This is a high-power photomicrograph of gitter cells (arrows).
File:IPLab3BrainInfarction9.jpg|This is a photomicrograph of the edge of the infarct. Note the gitter cells, gemistocytic astrocytes, and some hemosiderin-laden macrophages (arrows).
File:IPLab3BrainInfarction10.jpg|This is a gross photograph of a brain from another patient with an old healed infarct. Note the meninges overlying the infarcted region (arrow).
File:IPLab3BrainInfarction10.jpg|This is a gross photograph of a brain from another patient with an old healed infarct. Note the meninges overlying the infarcted region (arrow).
File:IPLab3BrainInfarction11.jpg|This is a closer view of the brain demonstrating an old healed infarct with the meninges containing blood vessels (arrow) overlying the infarcted region.  
File:IPLab3BrainInfarction11.jpg|This is a closer view of the brain demonstrating an old healed infarct with the meninges containing blood vessels (arrow) overlying the infarcted region.  
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