Pathology Education Instructional Resource

Cytologically Yours: CoW: 20140220: Difference between revisions

Created page with "== Clinical Summary == The patient is a 58 year old male with back and neck pain. === Past Medical History === * Cervical spondylosis * Hypertension * Hyperlipidemia === Pa..."
 
 
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===Cytology===
===Cytology===
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CytologicallyYoursCoW20140220Cytology1.jpg|40x magnification of highly atypical malignant appearing cells.
CytologicallyYoursCoW20140220Cytology1.jpg|20x magnification of a cellular specimen with numerous follicles and absent colloid.
CytologicallyYoursCoW20140220Cytology2.jpg|20x magnification showing osteoid formation.
CytologicallyYoursCoW20140220Cytology2.jpg|40x magnification with follicular cells forming microfollicular groups and inspissated colloid.
CytologicallyYoursCoW20140220Cytology3.jpg|40x magnification showing osteoid formation and malignant appearing cells.
CytologicallyYoursCoW20140220Cytology3.jpg|60x magnification with follicular cells forming microfollicular groups and inspissated colloid. Nuclear are crowded with overlapping. The nuclei are enlarged.
CytologicallyYoursCoW20140220Cytology4.jpg|40x magnification showing osteoid formation and malignant appearing cells.
CytologicallyYoursCoW20140220Cytology4.jpg|40x magnification with follicular cells forming a microfollicular group and inspissated colloid.
CytologicallyYoursCoW20140220Cytology5.jpg|40x magnification of osteoid.
CytologicallyYoursCoW20140220Cytology5.jpg|40x magnification of Pap stained material showing magnification with follicular cells forming microfollicular groups and inspissated colloid..
CytologicallyYoursCoW20140220Cytology6.jpg|60x magnification of Pap stained material with microfollicles.


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====Resident Questions====
====Resident Questions====
* <spoiler text="What is the differential diagnosis?"> In a cellular thyroid lesion, follicular neoplasm, including adenoma and carcinoma, and cellular benign follicular nodule are in the differential. Also in the differential is the follicular variant of papillary carcinoma.  </spoiler>
* <spoiler text="What is the differential diagnosis?"> In a cellular thyroid lesion, follicular neoplasm, including adenoma and carcinoma, and cellular benign follicular nodule are in the differential. Also in the differential is the follicular variant of papillary carcinoma.  </spoiler>
* <spoiler text="What are the molecular features that differentiate follicular carcinoma and papillary carcinoma?>"> Follicular carcinoma show PAX8-PPAR gamma translocations and papillary carcinoma shows BRAF mutations and RET/PTC rearrangements. </spoiler>


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