IPLab:Lab 6:Glomerulonephritis: Difference between revisions - Pathology Education Instructional Resource

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== Clinical Summary ==

This 17-year-old ~~white~~ male had end-stage renal disease requiring hemodialysis for 10 years. For the previous four years he had hypertension which slowly increased to about 180/120 mm Hg. Laboratory findings included a ~~greatly~~ elevated BUN and creatinine. He ~~was admitted for~~ bilateral nephrectomy and ~~discharged in satisfactory condition~~ on the ~~10th postoperative day. He was to be contacted in the future for transplantation~~.

This 27-year-old male had end-stage renal disease requiring hemodialysis for 10 years. For the previous four years he had hypertension which slowly increased to about 180/120 mm Hg. Laboratory findings included a markedly elevated BUN and creatinine. He underwent bilateral nephrectomy and was placed on the transplant list.

~~== Autopsy Findings ==~~

On examination the kidneys were similar in appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.

~~The left (97 grams) and right (88 grams)~~ kidneys were of similar appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.

== Images ==

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File:IPLab6GN10.jpg|For comparison this is an immunofluorescent photomicrograph of a glomerulus from a patient with Goodpasture's syndrome. The linear (arrows) immunofluorescence is characteristic of Goodpasture's syndrome.

</gallery>

== Virtual Microscopy ==

<peir-vm>IPLab6GN</peir-vm>

== Study Questions ==

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=== Journal Articles ===

* Lan HY, Yang N, Nikolic-Paterson DJ, Yu XQ, Mu W, Isbel NM, Metz CN, Bucala R, Atkins RC. [http://www.ncbi.nlm.nih.gov/pubmed/10652026 Expression of macrophage migration inhibitory factor in human glomerulonephritis]. ''Kidney Int'' 2000 Feb;57(2):499-509.

=== Images ===

* [{{SERVER}}/library/index.php?/tags/226-glomerulonephritis PEIR Digital Library: Glomerulonephritis Images]

* [http://library.med.utah.edu/WebPath/RENAHTML/RENALIDX.html#8 WebPath: Glomerulonephritis]

== Related IPLab Cases ==

* [[IPLab:Lab 1:Kidney Infarction|Lab 1: Kidney: Infarction (Coagulative Necrosis)]]

[[Category: IPLab:Lab 6]]

@@ Line 1: / Line 1: @@
 == Clinical Summary ==
-This 17-year-old white male had end-stage renal disease requiring hemodialysis for 10 years. For the previous four years he had hypertension which slowly increased to about 180/120 mm Hg. Laboratory findings included a greatly elevated BUN and creatinine. He was admitted for bilateral nephrectomy and discharged in satisfactory condition on the 10th postoperative day. He was to be contacted in the future for transplantation.
+This 27-year-old male had end-stage renal disease requiring hemodialysis for 10 years. For the previous four years he had hypertension which slowly increased to about 180/120 mm Hg. Laboratory findings included a markedly elevated BUN and creatinine. He underwent bilateral nephrectomy and was placed on the transplant list.
-== Autopsy Findings ==
+On examination the kidneys were similar in appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.
-The left (97 grams) and right (88 grams) kidneys were of similar appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.
 == Images ==
@@ Line 18: / Line 17: @@
 File:IPLab6GN10.jpg|For comparison this is an immunofluorescent photomicrograph of a glomerulus from a patient with Goodpasture's syndrome. The linear (arrows) immunofluorescence is characteristic of Goodpasture's syndrome.
 </gallery>
+== Virtual Microscopy ==
+<peir-vm>IPLab6GN</peir-vm>
 == Study Questions ==
@@ Line 34: / Line 36: @@
 === Journal Articles ===
+* Lan HY, Yang N, Nikolic-Paterson DJ, Yu XQ, Mu W, Isbel NM, Metz CN, Bucala R, Atkins RC.  [http://www.ncbi.nlm.nih.gov/pubmed/10652026 Expression of macrophage migration inhibitory factor in human glomerulonephritis].  ''Kidney Int'' 2000 Feb;57(2):499-509.
 === Images ===
+* [{{SERVER}}/library/index.php?/tags/226-glomerulonephritis PEIR Digital Library: Glomerulonephritis Images]
+* [http://library.med.utah.edu/WebPath/RENAHTML/RENALIDX.html#8 WebPath: Glomerulonephritis]
 == Related IPLab Cases ==
+* [[IPLab:Lab 1:Kidney Infarction|Lab 1: Kidney: Infarction (Coagulative Necrosis)]]
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]