Cytologically Yours: Unknowns: 201311: Case 2: Difference between revisions
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==Clinical History== | ==Clinical History== | ||
48 year old male with a | 48 year old male with a 3.5 cm thyroid nodule on ultrasound. | ||
==Cytology== | ==Cytology== | ||
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CytologicallyYoursUnknowns201311-2-01.jpg | CytologicallyYoursUnknowns201311-2-01.jpg | ||
CytologicallyYoursUnknowns201311-2-02.jpg | CytologicallyYoursUnknowns201311-2-02.jpg | ||
CytologicallyYoursUnknowns201311-2-03.jpg | |||
</gallery> | </gallery> | ||
===Resident Questions=== | ===Resident Questions=== | ||
* <spoiler text="Diagnosis?"> | * <spoiler text="Diagnosis?"> | ||
* Follicular neoplasm </spoiler | * Follicular neoplasm). </spoiler> | ||
* <spoiler text="What are the most common molecular associations | * <spoiler text="What are the most common molecular associations?"> | ||
* Ras | * Ras mutation in 49%. | ||
* PAX8-PPAR gamma | * PAX8-PPAR gamma rearrangements in 36%. | ||
</spoiler> | |||
==Cytologic Features== | |||
* Microfollicles and trabeculae | |||
* Cellular crowding | |||
* Cellular aspirate | |||
* Little to absent colloid | |||
* Monotony | |||