Difference between revisions of "Cytologically Yours: Unknowns: 201311: Case 1"

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(Created page with "==Clinical History== 45 year old female with hypothyroidism. ==Cytology== <gallery heights="250px" widths="250px"> CytologicallyYoursUnknowns201311-1-01.jpg CytologicallyYour...")
 
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===Resident Questions===
 
===Resident Questions===
* <spoiler text="Diagnosis?">Lymphocytic thyroiditis (Hashimoto thyroiditis). </spoiler>
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* <spoiler text="Diagnosis?">
 +
* Lymphocytic thyroiditis (Hashimoto thyroiditis). </spoiler>
 
* <spoiler text="What are the clinical findings that support this diagnosis?">
 
* <spoiler text="What are the clinical findings that support this diagnosis?">
 
* The diagnosis of Hashimoto is based on one or more circulating autoantibodies. The most common are anti-thyroglobulin and anti-thyroid peroxidase (TPO).
 
* The diagnosis of Hashimoto is based on one or more circulating autoantibodies. The most common are anti-thyroglobulin and anti-thyroid peroxidase (TPO).
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==Additional Teaching Points==
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===Immunohistochemistry===
 
* TTF-1 (nuclear stain)
 
** Thyroid Transcription factor1 regulates transcription of genes specific to the thyroid, lung, and diencephalon
 
** If metastatic thyroid cancer to the lung is ruled out by morphology or +thyroglobulin; then a +TTF1 supports adenocarcinoma originating from the lung
 
* P63 (nuclear stain) and 34BE12 (cytoplasmic stain)
 
** Used for squamous differentiation
 
* TTF1 is more sensitive than p63
 
** If a tumor stains for both it is more likely to be adenocarcinoma
 
* Napsin A(cytoplasmic stain)
 
** Granular staining pattern
 
** Marker for adenocarcinoma
 
  
 
{{Cytologically Yours}}
 
{{Cytologically Yours}}

Revision as of 15:40, 10 January 2014

Clinical History

45 year old female with hypothyroidism.

Cytology


Resident Questions