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* <spoiler text="What is the most common cause of trisomy?">Meiotic nondisjunction.</spoiler>
* <spoiler text="What are some common physical/clinical abnormalities seen in Down syndrome?">Epicanthic folds and flat facial profile, low set ears, simian crease, congenital heart defects, intestinal stenosis, umbilical hernia, hypotonia, predisposition to leukemia.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/943216-overview eMedicine Medical Library: Down Syndrome]
* [http://emedicine.medscape.com/article/945649-overview eMedicine Medical Library: Klinefelter Syndrome]
* [http://emedicine.medscape.com/article/949681-overview eMedicine Medical Library: Turner Syndrome]
* [http://www.merckmanuals.com/professional/pediatrics/chromosomal_anomalies/overview_of_chromosomal_anomalies.html Merck Manual: Chromosomal Abnormalities]
=== Journal Articles ===
* Garcia-Heras J, Rao PN. [http://www.ncbi.nlm.nih.gov/pubmed/10334476 A brief review of cryptic duplications of 21q as an emerging cause of Down syndrome: practical considerations for accurate detection]. ''Clin Genet'' 1999 Mar;55(3):207-11.
=== Images ===
* [http://peir.path.uab.edu/library/index.php?/tags/788-downs_syndrome PEIR Digital Library: Down Syndrome Images]
* [http://peir.path.uab.edu/library/index.php?/category/143 PEIR Digital Library: Genetics Images]
* [http://library.med.utah.edu/WebPath/PEDHTML/PEDIDX.html WebPath: Pediatric-Perinatal Pathology]
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[[Category: IPLab:Lab 5]]