Cytologically Yours: Unknowns: 201311: Case 2

Clinical History

48 year old male with a 3.5 cm thyroid nodule on ultrasound.

Cytology

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Resident Questions

• Diagnosis?

• Follicular neoplasm).

• What are the most common molecular associations?

• Ras mutation in 49%.
• PAX8-PPAR gamma rearrangements in 36%.

Cytologic Features

• Microfollicles and trabeculae
• Cellular crowding
• Cellular aspirate
• Little to absent colloid
• Monotony