KARYOTYPE: HEMATOLOGIC: BONE MARROW: Myelodysplastic syndrome (MDS), Agnogenic myeloid metaplasia, myelofibrosis, karyotype; Trisomy 8 or +8 is most common karyotype abnormality in MDS, and acute nonlymphocytic leukemias. Besa/Peter C. Nowell, M.D. Karyotype Slides