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IPLab:Lab 8:HSV Encephalitis

53 bytes added, 16:28, 3 January 2014
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== Clinical Summary ==
This 30-year-old white male experienced a generalized tonic-clonic seizure and was subsequently started on a course of Dilantin. He did well, but later developed a headache lasting over a week, which was associated with tonic-clonic seizures, fever, and--toward the end of this period--ataxia. The patient improved and returned to work, but the headache returned. A lumbar puncture was then performed which showed 22 cells/cmm mm³ (all lymphocytes), protein of 88 grams/L, and a glucose level of 49 mg/dL (with a simultaneous serum glucose of 83 mg/dL). These findings were compatible with a viral infection. Despite therapy, the patient had another seizure and again developed fever. At that time, a brain biopsy was performed which showed herpetic encephalitis. Despite aggressive antiviral therapy the patient died.
== Images ==
IPLab8HSVEncephalitis12.jpg|This is a photomicrograph of a brain section stained with an antibody against herpes simplex. Even at this magnification, it is easy to pick out cells that are positive for the virus (arrows).
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== Virtual Microscopy ==
<peir-vm>IPLab8HSVEncephalitis</peir-vm>
== Study Questions ==
=== Images ===
* [http://peir.path.uab.edu{{SERVER}}/library/index.php?/tags/127-herpes PEIR Digital Library: Herpes Images]
* [http://library.med.utah.edu/WebPath/CNSHTML/CNSIDX.html#6 WebPath: CNS Infections]
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