Difference between revisions of "IPLab:Lab 7:IDC"

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This 66-year-old female had had a mass of increasing size in the left breast for many years. A modified radical mastectomy was performed. At that time, invading carcinoma was left around the subclavian artery and 9 of 9 axillary lymph nodes were found to contain metastases. Later, pleural effusions recurred despite radiation therapy. The patient died 3 months after surgery.
 
This 66-year-old female had had a mass of increasing size in the left breast for many years. A modified radical mastectomy was performed. At that time, invading carcinoma was left around the subclavian artery and 9 of 9 axillary lymph nodes were found to contain metastases. Later, pleural effusions recurred despite radiation therapy. The patient died 3 months after surgery.
  
== Autopsy Findings ==
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At autopsy the left breast was large (1700 grams), measuring 34 x 22 x 7 cm. A very large tumor involving all quadrants and measuring about 14 cm in diameter was noted. The nipple and skin were involved, the latter showing the typical orange peel appearance. On section, virtually the entire breast was replaced by a tumor composed of firm, yellowish-white tissue. Extension into the fatty tissue and to the skin was evident grossly.
The left breast was large (1700 grams), measuring 34 x 22 x 7 cm. A very large tumor involving all quadrants and measuring about 14 cm in diameter was noted. The nipple and skin were involved, the latter showing the typical orange peel appearance. On section, virtually the entire breast was replaced by a tumor composed of firm, yellowish-white tissue. Extension into the fatty tissue and to the skin was evident grossly.  
 
  
 
== Images ==
 
== Images ==
 
<gallery heights="250px" widths="250px">
 
<gallery heights="250px" widths="250px">
File:IPLab7IDC1.jpg|This is a gross photograph of the surgical specimen of breast with infiltrating duct carcinoma. Note the tumor tissue under the area of the nipple. The tumor infiltrates in an irregular fashion into the breast parenchyma. Note the nipple retraction caused by this neoplasm.  
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File:IPLab7IDC1b.jpg|This is a gross photograph of the surgical specimen of breast with infiltrating duct carcinoma. Note the tumor tissue under the area of the nipple. The tumor infiltrates in an irregular fashion into the breast parenchyma. Note the nipple retraction caused by this neoplasm.  
 
File:IPLab7IDC2.jpg|These are sections of normal breast (lower) and breast tissue with infiltrating duct carcinoma (upper). Note the increased cellularity (increased blue staining due to the increased number of nuclei) in the tumor tissue.  
 
File:IPLab7IDC2.jpg|These are sections of normal breast (lower) and breast tissue with infiltrating duct carcinoma (upper). Note the increased cellularity (increased blue staining due to the increased number of nuclei) in the tumor tissue.  
 
File:IPLab7IDC3.jpg|This is a section of breast with small groups of carcinoma cells throughout the breast tissue and invading through the dermis.  
 
File:IPLab7IDC3.jpg|This is a section of breast with small groups of carcinoma cells throughout the breast tissue and invading through the dermis.  
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File:IPLab7IDC8.jpg|This is a high-power photomicrograph demonstrating the growth pattern of the tumor. The tumor consists of malignant duct-lining cells growing in cords, solid cell nests, tubules, and glands. The cytologic detail of tumor cells varies from small cells with moderately hyperchromatic, regular nuclei to large cells with large, irregular, hyperchromatic nuclei.  
 
File:IPLab7IDC8.jpg|This is a high-power photomicrograph demonstrating the growth pattern of the tumor. The tumor consists of malignant duct-lining cells growing in cords, solid cell nests, tubules, and glands. The cytologic detail of tumor cells varies from small cells with moderately hyperchromatic, regular nuclei to large cells with large, irregular, hyperchromatic nuclei.  
 
</gallery>
 
</gallery>
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== Virtual Microscopy ==
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=== Infiltrating Ductal Carcinoma ===
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<peir-vm>IPLab7IDC</peir-vm>
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=== Normal Breast ===
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<peir-vm>IPLab7IDC_Normal_Breast</peir-vm>
  
 
== Study Questions ==
 
== Study Questions ==
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=== Journal Articles ===
 
=== Journal Articles ===
 
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* Virnig BA, Tuttle TM, Shamliyan T, Kane RL.  [http://www.ncbi.nlm.nih.gov/pubmed/20071685 Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes].  ''J Natl Cancer Inst'' 2010 Feb 3;102(3):170-8.
  
 
=== Images ===
 
=== Images ===
 
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* [{{SERVER}}/library/index.php?/tags/138-breast/112-carcinoma PEIR Digital Library: Breast Carcinoma Images]
  
 
== Related IPLab Cases ==
 
== Related IPLab Cases ==
 
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* [[IPLab:Lab 7:Fibroadenoma|Lab 7: Breast: Fibroadenoma]]
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* [[IPLab:Lab 7:Bronchogenic Carcinoma|Lab 7: Lung: Bronchogenic Carcinoma]]
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* [[IPLab:Lab 7:Lip SCC|Lab 7: Lip: Squamous Cell Carcinoma]]
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* [[IPLab:Lab 7:Esophagus SCC|Lab 7: Esophagus: Squamous Cell Carcinoma]]
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* [[IPLab:Lab 7:Adenocarcinoma|Lab 7: Colon: Adenocarcinoma]]
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* [[IPLab:Lab 7:Metastatic Adenocarcinoma|Lab 7: Lung & Liver: Metastatic Adenocarcinoma]]
  
 
{{IPLab 7}}
 
{{IPLab 7}}
  
 
[[Category: IPLab:Lab 7]]
 
[[Category: IPLab:Lab 7]]

Latest revision as of 02:03, 9 July 2020

Clinical Summary[edit]

This 66-year-old female had had a mass of increasing size in the left breast for many years. A modified radical mastectomy was performed. At that time, invading carcinoma was left around the subclavian artery and 9 of 9 axillary lymph nodes were found to contain metastases. Later, pleural effusions recurred despite radiation therapy. The patient died 3 months after surgery.

At autopsy the left breast was large (1700 grams), measuring 34 x 22 x 7 cm. A very large tumor involving all quadrants and measuring about 14 cm in diameter was noted. The nipple and skin were involved, the latter showing the typical orange peel appearance. On section, virtually the entire breast was replaced by a tumor composed of firm, yellowish-white tissue. Extension into the fatty tissue and to the skin was evident grossly.

Images[edit]

Virtual Microscopy[edit]

Infiltrating Ductal Carcinoma[edit]

Normal Breast[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

Related IPLab Cases[edit]

A radical mastectomy involves removal of the breast, underlying pectoralis muscles, and axillary lymph nodes.

Pleural effusion is the presence of fluid in the pleural space. Increased hydrostatic pressure in the pulmonary vasculature, as seen in heart failure, is one cause of pleural effusion.

An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.