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This 55-year-old white male had a long history of emphysema and a 60-70 pack-year smoking history. He was in his usual state of health until about one month before admission, at which time he developed increasing dyspnea on exertion. At the same time, his sputum increased from two tablespoons to half a cup of yellow blood-streaked sputum a day. Chest x-ray showed a right hilar mass. Sputum cytology revealed abnormal cells that were "positive for malignancy." He later developed pneumonia and fever. The patient expired soon thereafter.
== Images ==
File:IPLab7Bronchogenic3.jpg|This is a photomicrograph of bronchus with ulcerated mucosal surface on the right (1). The submucosa is completely filled with tumor down to the cartilage (2).
File:IPLab7Bronchogenic4.jpg|This is a higher-power photomicrograph of bronchus with the ulcerated mucosal surface on the right and tumor underneath.
File:IPLab7Bronchogenic5IPLab7Bronchogenic5x.jpg|This is a higher-power photomicrograph of the mucosal surface (right) with an area of hemorrhage (arrow) and underlying tumor (left). File:IPLab7Bronchogenic6.jpg|This is a photomicrograph of tumor from an area of invasion with compression of fibrous stroma and focal necrosis. File:IPLab7Bronchogenic7.jpg|This is a high-power photomicrograph showing cytologic detail of the tumor cells with an area foci of necrosis (1) and a more differentiated area with keratin pearl formation (2arrows). File:IPLab7Bronchogenic8IPLab7Bronchogenic6b.jpg|This is a high power photomicrograph of tumor cells with an area of central necrosis (arrow)more keratin production. File:IPLab7Bronchogenic9IPLab7Bronchogenic8b.jpg|This high-power photomicrograph of tumor shows the cytologic detail keratin production and areas of a less-differentiated area of neoplasm with cellular anaplasianecrosis (N).
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== Virtual Microscopy ==
<peir-vm>IPLab7Bronchogenic</peir-vm>
== Study Questions ==
# serotonin, associated with the carcinoid syndrome. The incidence of clinically significant syndromes related to these factors ranges from 1 to 10% of all lung cancer patients. Any one of the histologic types of tumors may occasionally produce any one of the hormones, but tumors producing ACTH and ADH are predominantly small cell carcinomas and those producing hypercalcemia are mostly squamous cell tumors.</spoiler>
* <spoiler text="What is the prognosis for patients with bronchiogenic carcinoma?">The clinical course is somewhat variable but in general the prognosis is poor with a 5 year survival of approximately 9%.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/279960-overview eMedicine Medical Library: Non-Small Cell Lung Cancer]
* [http://emedicine.medscape.com/article/1689988-overview eMedicine Medical Library: Genetics of Non-Small Cell Lung Cancer]
* [http://emedicine.medscape.com/article/280104-overview eMedicine Medical Library: Small Cell Lung Cancer]
* [http://www.merckmanuals.com/professional/pulmonary_disorders/tumors_of_the_lungs/lung_carcinoma.html Merck Manual: Lung Carcinoma]
=== Journal Articles ===
* Hyer JD, Silvestri G. [http://www.ncbi.nlm.nih.gov/pubmed/10763092 Diagnosis and staging of lung cancer]. ''Clin Chest Med'' 2000 Mar;21(1):95-106, viii-ix.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/27-lung/112-carcinoma PEIR Digital Library: Lung Carcinoma Images]
* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html WebPath: Pulmonary Pathology]
== Related IPLab Cases ==
* [[IPLab:Lab 7:Lip SCC|Lab 7: Lip: Squamous Cell Carcinoma]]
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* [[IPLab:Lab 7:IDC|Lab 7: Breast: Infiltrating Ductal Carcinoma]]
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{{IPLab 7}}
[[Category: IPLab:Lab 7]]
