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→Virtual Microscopy
File:IPLab3ForeignBodyGranuloma5.jpg|This is a fully-polarized view of lung showing numerous birefringent particles.
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== Virtual Microscopy ==
=== Lung: Foreign Body Granulomas ===
<peir-vm>IPLab3ForeignBodyGranuloma</peir-vm>
=== Normal Lung ===
<peir-vm>UAB-Histology-00107</peir-vm>
== Study Questions ==
* <spoiler text="Compare and contrast the tissue reactions to carbon (anthracosis), talc, and silica. What factors are important in the pathogenesis of tissue injury due to these foreign materials?">Carbon is relatively inert and leads to little if any tissue damage.
* whether the materials can be phagocytosed and removed from the body or whether they damage leukocytes and cause the release of inflammatory mediators.</spoiler>
* <spoiler text="What are the birefringent particles seen in the nodules adjacent to the vessels and how did they get there?">The material is talc, which is often used to "cut" street drugs. Intravenous injection of talc leads to some talc being deposited in tissues and initiating an inflammatory response.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/287790-overview eMedicine Medical Library: Opioid Abuse]
* [http://www.merckmanuals.com/professional/special_subjects/drug_use_and_dependence/opioids.html Merck Manual: Opioids: Drug Use and Dependence]
* [http://www.merckmanuals.com/home/lung_and_airway_disorders/environmental_lung_diseases/occupational_asthma.html Merck Manual: Occupational Asthma]
=== Journal Articles ===
* Nan DN, Fernández-Ayala M, Iglesias L, García-Palomo D, Parra JA, Fariñas MC. [http://www.ncbi.nlm.nih.gov/pubmed/10893392 Talc granulomatosis. A differential diagnosis of interstitial lung disease in HIV patients]. ''Chest'' 2000 Jul;118(1):258-60.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/526-talc_granuloma PEIR Digital Library: Talc Granuloma Images]
* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html#10 WebPath: Interstitial Lung Diseases]
== Related IPLab Cases ==
* [[IPLab:Lab 4:Thromboembolus|Lab 4: Lung: Thromboembolus]]
{{IPLab 3}}
[[Category:IPLab:Lab 3]]