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→Clinical Summary
== Clinical Summary ==
About three weeks before his death, this 17-year-old white male developed a "chest cold" which gradually worsened. The patient was eventually admitted three days before his death. At that time, the patient was very dyspneic. Chest x-ray showed consolidation of the entire left lung. The initial impression by his care team was staphylococcal pneumonia. However, Blastomyces dermatitides was identified in stained smears of sputum the next day. In spite of appropriate antifungal therapy, the patient deteriorated rapidly and died.
== Images ==
File:IPLab10Blasto10.jpg|This is a very high-power photomicrograph showing Blastomyces organisms stained with PAS. Note the budding organism (arrow) and the underlying pyogranulomatous inflammatory reaction in the background.
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== Virtual Microscopy ==
=== H&E ===
<peir-vm>IPLab10Blasto_HE</peir-vm>
=== PAS ===
<peir-vm>IPLab10Blasto_PAS</peir-vm>
== Study Questions ==
* <spoiler text="What groups of people are at increased risk for Blastomyces?">Those exposed to dust--construction workers exposed to dust from construction sites, hunters and outdoors people who walk in dusty areas, and farm workers.</spoiler>
* <spoiler text="What is the usual clinical manifestation of Blastomyces infection?">Most patients get a pyogranulomatous pneumonia. However, Blastomyces can spread outside the lungs to the skin, bones, and prostate.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/354067-overview eMedicine Medical Library: Imaging in Thoracic Blastomycosis]
* [http://emedicine.medscape.com/article/296870-overview eMedicine Medical Library: Blastomycosis]
* [http://www.merckmanuals.com/professional/infectious_diseases/fungi/blastomycosis.html Merck Manual: Blastomycosis]
=== Journal Articles ===
* Rooney PJ, Klein BS. [http://www.ncbi.nlm.nih.gov/pubmed/11906450 Linking fungal morphogenesis with virulence]. ''Cell Microbiol'' 2002 Mar;4(3):127-37.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/542-blastomycosis PEIR Digital Library: Blastomycosis Images]
* [http://library.med.utah.edu/WebPath/INFEHTML/INFECIDX.html Webpath: Infection]
{{IPLab 10}}
[[Category: IPLab:Lab 10]]