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Pathology Education Instructional Resource β

Cytologically Yours: Unknowns: 201311: Case 5


Clinical History

69 year old female with 1.2cm thyroid nodule.


Resident Questions

Cytologic Features

  • Pure Hurthle cell population
  • Prominent nucleolus
  • Pseudopsammoma bodies (Basophlic structures thought to be colloid, with concentric lamellae)
  • Shows either small cell dysplasia (smaller cells with high N/C ratio) or large cell dysplasia (large cells with at least 2x variability in nuclear size)
  • No lymphocytes