This 57-year-old white male with a 25-year history of Type I 1 diabetes mellitus (insulin-dependent ) developed an acute myocardial infarction followed by cerebral infarction, pulmonary dysfunction, and renal failure. There was a history of hypertension , proteinuria, and proteinuria. Laboratory findings included a elevations in BUN and creatinine . He subsequently died of 69 mg/dL multisystem failure. The autopsy showed concentric left ventricular hypertrophy, an acute myocardial infarction, and 3a right cerebral infarction.3 mg/dL which subsequently rose to 113 The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and 4arteriolosclerosis.8The kidneys were large, weighing 220 and 240 grams respectively. He subsequently died , and had a rough surface, a few cortical scars, and blurring of multisystem failurethe corticomedullary junctions.