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File:IPLab3Sarcoidosis1.jpg|This is a low-power photomicrograph of a lymph node. Note the rather pale-pink color of the tissue with dark-staining cells found in only a few scattered areas. These darker cells represent the original lymphocytes of this lymphoid organ.
File:IPLab3Sarcoidosis2IPLab3Sarcoidosis2b.jpg|This photomicrograph of lymph node tissue illustrates a paucity of lymphocytes as well as numerous small, pale-staining nodules (arrows) throughout the tissue.File:IPLab3Sarcoidosis3IPLab3Sarcoidosis3b.jpg|This is a photomicrograph of the small nodules (arrows) seen in the previous image. Close examination reveals that they are composed of large macrophages (epithelioid macrophages). These small granulomas form multiple series of reaction centers throughout the lymph node. Note the remaining lymphocytes surrounding the granulomas.
File:IPLab3Sarcoidosis4.jpg|This photomicrograph of a single granuloma illustrates the individual macrophages (arrows) which make up the bulk of this tissue. There is an absence of necrosis in the center of the lesions in this case.
File:IPLab3Sarcoidosis5IPLab3Sarcoidosis5b.jpg|This is a photomicrograph of a multinucleated giant cell (1). In the center of this foreign body-containing giant cell there is a small asteroid body (2). There is no functional significance to this asteroid body.File:IPLab3Sarcoidosis6.jpg|This is a higher-power photomicrograph of an asteroid body (arrow) inside of a multinucleated giant cell.
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=== Lymph Node ===
<peir-vm>UAB-Histology-00035</peir-vm>
== Study Questions ==
* <spoiler text="What is sarcoidosis?">The exact cause of sarcoidosis is unknown. Sarcoidosis is characterized by non-caseating granulomas in many tissues and organs.</spoiler>
* <spoiler text="What is the characteristic phenotype of sarcoid granulomas?">The typical characteristic of a sarcoid granuloma is a non-caseating granuloma which consists of an aggregate of tightly-clustered epitheliod cells, often with Langhans’ or multinucleated giant cells. Occasionally, asteroid bodies may be seen.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/809047-overview eMedicine Medical Library: Acute Complications of Sarcoidosis]* [http://emedicine.medscape.com/article/301914-overview eMedicine Medical Library: Sarcoidosis]* [http://emedicine.medscape.com/article/1123970-overview eMedicine Medical Library: Dermatologic Manifestations of Sarcoidosis]* [http://emedicine.medscape.com/article/1147324-overview eMedicine Medical Library: Neurosarcoidosis]* [http://www.merckmanuals.com/professional/pulmonary_disorders/sarcoidosis/sarcoidosis.html Merck Manual: Sarcoidosis]
=== Journal Articles ===
* Drent M, Crouser ED, Grunewald J. [https://www.nejm.org/doi/full/10.1056/NEJMra2101555 Challenges of Sarcoidosis and Its Management]. ''N Engl J Med'' 2021; 385:1018-1032* English JC, Patel PJ, Greer KE. [http://www.mdconsult.com/das/article/body/421068364-2/jorg=journal&source=MI&sp=11817316&sid=119276088/N/217466/1.html?issn= Sarcoidosis]. ''J Am Acad Dermatol'' 2001;44:725-43* Johns CJ, Michele TM. [http://www.ncbi.nlm.nih.gov/pubmed/10195091 The clinical management of sarcoidosis. A 50-year experience at the Johns Hopkins Hospital]. ''Medicine (Baltimore)'' 1999 Mar;78(2):65-111.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/531-sarcoidosis PEIR Digital Library: Sarcoidosis Images]
* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html#2 WebPath: Granulomatous Disease]
{{IPLab 3}}
[[Category: IPLab:Lab 3]]