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4) a widely disseminated involvement, particularly in immunosuppressed patients.</spoiler>
* <spoiler text=" How do Histoplasma organisms infect cells?"> <Histoplasma conidia and yeasts bind to the beta-chain of the integrins receptors LFA-1 (CD11a/spoiler>CD18) and MAC-1 (CD11b/CD18). * <spoiler text=" "> Histoplasma yeasts are phagocytosed by the unstimulated macrophages, multiply within the phagolysosome, and lyse the host cells.</spoiler>
{{IPLab 10}}
[[Category: IPLab:Lab 10]]