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• 21:57, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6AcuteRejection6.jpg (This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium. There is some degeneration (coagulative necrosis) of tubules and glomeruli.)
• 21:57, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6AcuteRejection5.jpg (This is a higher-power photomicrograph demonstrating the cellular infiltrate within the interstitium and around the small blood vessel in the center of the image.)
• 21:57, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6AcuteRejection4.jpg (This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section. Note that in addition to the diffuse cellularity, the focal accumulations of cells appear to be focused around blood vessels.)
• 21:56, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6AcuteRejection3.jpg (This is a higher-power photomicrograph demonstrating the cellular infiltrates within this kidney section.)
• 21:56, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6AcuteRejection2.jpg (This is a low-power photomicrograph of the kidney that was removed from this patient. Even at this low power you can appreciate the focal accumulations of cells within this section and the diffuse cellular infiltrate (blue dots) throughout the kidney p...)
• 21:56, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6AcuteRejection1.jpg (This is a gross photograph of a kidney with acute rejection from an autopsy case. Note that the kidney is swollen (edema and inflammation) and there are areas of hemorrhage throughout the kidney.)
• 21:51, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection12.jpg (Photomicrograph from another region of previous image. Note the cellular infiltrate around a small blood vessel (right) and neutrophils within renal tubules (arrow).)
• 21:51, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection11.jpg (This is a higher-power photomicrograph of kidney from the previous image demonstrating the cellular infiltrate which is comprised of lymphocytes, macrophages, plasma cells and a few neutrophils.)
• 21:50, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection10.jpg (This is a high-power photomicrograph of a kidney from another case of chronic transplant rejection. In this case there is extensive damage to the kidney due to the chronic rejection (loss of tubules and glomerular lesions). In addition, this kidney was...)
• 21:50, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection9.jpg (This is a high-power photomicrograph of a damaged glomerulus. Note the loss of normal capillary structure, the mesangial expansion and the infiltration of large mononuclear cells.)
• 21:50, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection8.jpg (This is a high-power photomicrograph of renal cortex with cellular infiltrate and few remaining renal tubules. The cellular infiltrate comprises macrophages, activated (large) lymphocytes and a few neutrophils and plasma cells.)
• 21:49, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection7.jpg (This is a photomicrograph of a glomerulus with a mild cellular infiltrate (left) and a small damaged glomerulus (right). There is extensive interstitial fibrosis (1), loss of renal tubules, and the remaining tubules contain protein (2) indicating sever...)
• 21:49, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection6.jpg (This is a photomicrograph of rejected kidney with a focus of cellular infiltrate (left) and a small artery with neointimal proliferation and stenosis (arrow).)
• 21:49, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection5.jpg (This high-power photomicrograph of glomeruli from this kidney demonstrates congestion (1), increased cellularity of glomeruli with mesangial expansion, and a glomerulus that is almost completely obliterated or sclerosed (2).)
• 21:49, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection4.jpg (This is another area of renal cortex similar to the previous image. Note the fibrosis (1) and loss of renal tubules throughout this section. Also note the focus of inflammatory cells (2) indicating that despite the chromic nature of this lesion, there ...)
• 21:48, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection3.jpg (This is a photomicrograph of kidney with a focal area of hemorrhage around a small blood vessel (left) and congestion of the glomeruli. Note that there is a marked loss of renal tubules throughout this section with replacement by fibrous connective tis...)
• 21:48, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection2.jpg (This is a higher-power photomicrograph of kidney containing a section of blood vessel that demonstrates a marked neointimal proliferative response (1). In this case the lumen of the artery is obliterated. Also note the cellular infiltrate in the inters...)
• 21:48, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6ChronicRejection1.jpg (This is a low-power photomicrograph of the kidney from this case of chronic transplant rejection. Note the focal areas of hemorrhage and inflammatory cell infiltrate in this section.)
• 21:43, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6MM4.jpg (This is a photograph of the vertebral column from this patient at autopsy. Notice the collapsed vertebra (1). There are multiple variably-sized white nodules (2) within the bone marrow. These are accumulations of malignant plasma cells in this case of ...)
• 21:43, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6MM3.jpg (This high-power photomicrograph demonstrates the cells that make up this tissue. These cells resemble plasma cells and are the malignant cell of multiple myeloma.)
• 21:42, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6MM2.jpg (This higher-power photomicrograph shows the junction between an amorphous hyaline-appearing area (amyloid) on the right and cellular areas (plasmacytoid cells) on the left.)
• 21:42, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6MM1.jpg (This is a low-power photomicrograph of the mediastinal mass. The mass is encapsulated and contains cellular areas (blue) and areas of pale red material.)
• 21:36, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid11.jpg (This photomicrograph of the tongue demonstrates extensive amyloid deposits (1) separating the skeletal muscle fibers of the tongue. In many cases the amyloid encircles the muscle fibers (2) and these muscle fibers are atrophied.)
• 21:36, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid10.jpg (This photomicrograph of kidney demonstrates the amyloid deposits (arrows) within glomeruli.)
• 21:36, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid9.jpg (This is a gross photograph of kidney from this case. Note the pale yellow material within the cortex (arrows). This is indicative of amyloid within the cortex and the glomeruli. Also note that there are multiple red spots in the cortex. These represent...)
• 21:35, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid8.jpg (This is a photomicrograph of Congo-red-stained liver tissue viewed with partially polarized light. Although not well demonstrated in this image, Congo-red-stained amyloid viewed through polarized light should give off a classic “apple green” birefr...)
• 21:35, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid7.jpg (This is a high-power view of liver tissue stained with Congo red. The orange amyloid material (arrows) is seen clearly between liver parenchymal cells.)
• 21:35, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid6.jpg (This is a low-power photomicrograph of liver tissue stained with Congo red (orange color in slide). Congo red reacts with amyloid and gives it an orange color (arrows).)
• 21:34, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid5.jpg (This is a higher-power photomicrograph showing the amyloid deposits (1) between hepatocytes (2).)
• 21:34, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid4.jpg (This is a low-power photomicrograph of liver tissue from this case. Note the eosinophilic hyaline material (1) present within and between the hepatic tissue (2). There is marked distortion of lobular architecture by the amyloid.)
• 21:34, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid3.jpg (This is a closer view of the cut surface of this liver. The pale waxy material can be seen within the hepatic tissue (arrows).)
• 21:33, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid2.jpg (This is a gross picture of the cut surface of the liver from this case. The liver tissue is firm and has a waxy appearance--although this is difficult to appreciate in an image.)
• 21:33, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6Amyloid1.jpg (This is a gross picture of liver from this case. Note the pale, swollen appearance of this liver.)
• 20:25, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6SenileAmyloidosis5.jpg (This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.)
• 20:25, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6SenileAmyloidosis4.jpg (This is a higher-power photomicrograph of extracellular amyloid (1) and deposition of amyloid in the vessel wall (2).)
• 20:24, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6SenileAmyloidosis3.jpg (This is a higher-power photomicrograph of the heart tissue from this case. Note the amyloid deposition throughout the myocardium (1) as well as deposition in the wall of the blood vessel (2).)
• 20:24, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6SenileAmyloidosis2.jpg (This is a low power photomicrograph of the heart tissue from this case. At this magnification the structure looks relatively normal.)
• 20:24, 20 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6SenileAmyloidosis1.jpg (This is a gross photograph of section of heart tissue from this case. The tissue was firm and had a waxy texture. If you use your imagination you can see pale yellow areas within this tissue which represent the amyloid deposits.)
• 18:29, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab5Downs6.jpg (This is a karyotype of a patient with Turner syndrome (45, X).)
• 18:28, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab5Downs5.jpg (This is a karyotype of a patient with Klinefelter syndrome (47, XXY).)
• 18:28, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab5Downs4.jpg (FISH is also useful in the diagnosis of other genetic disorders. This is an example of FISH staining on another patient using a probe specific for DiGeorge's disease. The arrow shows that there is a deletion on chromosome 22, which is diagnostic for Di...)
• 18:28, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab5Downs3.jpg (Chromosomes from the chromosome spread are lined up to demonstrate the karyotype. In this case there are three copies of chromosome 21, just as noted in the FISH.)
• 18:27, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab5Downs2.jpg (These cells, obtained by amniocentesis, were cultured and then arrested in metaphase. Nuclei from these cells were isolated and stained to demonstrate the banding pattern of each chromosome. This photograph shows a "chromosome spread." Each chromosome ...)
• 18:27, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab5Downs1.jpg (This is a photomicrograph of cells obtained by amniocentesis that were stained using FISH. The cell in panel 1 was stained with markers specific for the X and Y-chromosomes. The cell in panel 2 was stained with a marker specific for chromosome 18. The ...)
• 18:23, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6GravesDisease7.jpg (Closer view of cut surface of the thyroid with nodular goiter. Note the multilobular appearance of the tissue.)
• 18:23, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6GravesDisease6.jpg (This is a gross photograph of a thyroid from a case of nodular goiter.)
• 18:23, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6GravesDisease5.jpg (This is a high-power photomicrograph of thyroid. Note the papillary projections and the moth-eaten appearance of the colloid. This appearance indicates active absorption of the colloid to form thyroglobulin.)
• 18:22, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6GravesDisease4.jpg (This is a high-power photomicrograph of thyroid. Note the cellularity of the tissue with marked infolding of the epithelial tissue.)
• 18:22, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6GravesDisease3.jpg (This is a higher-power photomicrograph of thyroid. The tissue is very cellular and there is little colloid.)
• 18:22, 19 August 2013 Seung Park (talk | contribs) uploaded File:IPLab6GravesDisease2.jpg (This is a low-power photomicrograph of thyroid tissue from this case. The tissue is very cellular with very little colloid.)

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