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* <spoiler text="Why is gout more severe in peripheral joints?">The decreased temperature accentuates the crystallization of monosodium urate (MSU).</spoiler>
* <spoiler text="What initiates the inflammatory reaction seen in the synovial membrane in gouty arthritis?">MSU crystals are chemotactic and they activate complement. This initiates a cascade of inflammatory events which leads to acute gouty arthritis.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/329958-overview eMedicine Medical Library: Gout and Pseudogout]
* [http://www.aafp.org/afp/1999/0215/p925.html American Academy of Family Physicians: Gout and Hyperuricemia]
=== Journal Articles ===
* Harris MD, Siegel LB, Alloway JA. [http://www.ncbi.nlm.nih.gov/pubmed/10068714 Gout and hyperuricemia]. ''Am Fam Physician'' 1999 Feb 15;59(4):925-34.
* Pittman JR, Bross MH. [http://www.ncbi.nlm.nih.gov/pubmed/10208700 Diagnosis and management of gout]. ''Am Fam Physician'' 1999 Apr 1;59(7):1799-806, 1810.
=== Images ===
* [http://peir.path.uab.edu/library/index.php?/tags/784-gout PEIR Digital Library: Gout Images]
== Related IPLab Cases ==
* [[IPLab:Lab 6:Rheumatoid Arthritis|Lab 6: Rheumatoid Arthritis]]
{{IPLab 5}}
[[Category: IPLab:Lab 5]]