IPLab:Lab 9:RMSF - Revision history

Peter Anderson: /* Clinical Summary */

2020-07-09T21:42:12Z

‎Clinical Summary

2020-07-09T21:41:00Z

‎Biopsy Findings

2014-01-03T16:31:25Z

2013-08-30T01:43:15Z

‎Images

2013-08-24T01:56:46Z

‎Related IPLab Cases

2013-08-24T01:56:34Z

‎Images

2013-08-24T01:53:55Z

‎Journal Articles

2013-08-24T01:53:10Z

‎Reference

2013-08-23T04:23:13Z

2013-08-21T15:52:49Z

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 == Clinical Summary ==
 This 9-year-old child was admitted with headache, fever, and a morbilliform rash on the arms and legs. There was a history of a tick being removed from her back. By the time a biopsy was performed, the rash had become petechial. Antibiotics were given and the child recovered within one week.
 == Images ==

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 == Clinical Summary ==
 This 9-year-old child was admitted with headache, fever, and a morbilliform rash on the arms and legs. There was a history of a tick being removed from her back. By the time a biopsy was performed, the rash had become petechial. Antibiotics were given and the child recovered within one week.
 == Images ==

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 File:IPLab9RMSF8.jpg|This is a high-power photomicrograph of a thrombosed vessel in the dermis. Note that the endothelial cells are missing along part of the circumference of the vessel (arrows)--this is where the main part of the thrombus has attached. Also note the inflammation surrounding the vessel.
 </gallery>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/2151-rmsf PEIR Digital Library: RMSF Images]
+* [{{SERVER}}/library/index.php?/tags/2151-rmsf PEIR Digital Library: RMSF Images]
 {{IPLab 9}}
 [[Category: IPLab:Lab 9]]

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 === Images ===
 * [http://peir.path.uab.edu/library/index.php?/tags/2151-rmsf PEIR Digital Library: RMSF Images]
 {{IPLab 9}}
 [[Category: IPLab:Lab 9]]

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 === Journal Articles ===
+* Pantanowitz L, Telford SR, Cannon ME.  [http://www.ncbi.nlm.nih.gov/pubmed/11982962 Tick-borne diseases in transfusion medicine].  ''Transfus Med'' 2002 Apr;12(2):85-106.
 === Images ===

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/228042-overview eMedicine Medical Library: Rocky Mountain Spotted Fever]
 === Journal Articles ===

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 * <spoiler text="What is the usual clinical course of Rocky Mountain Spotted Fever?">An eschar develops at the site of the tick bite followed by a hemorrhagic rash that extends over the entire body, including the palms of the hands and soles of the feet. The vascular lesions that underlie the rash often lead to acute necrosis, fibrin extravasation, and thrombosis of the small blood vessels, including arterioles. In severe RMSF, foci of necrotic skin can form on the fingers, toes, elbows, ears, and scrotum.</spoiler>
 * <spoiler text="How does Rickettsia rickettsii produce the vasculitis?">Rickettsiae predominantly infect host endothelial and vascular smooth muscle cells causing a widespread vasculitis that may be complicated by thrombi and hemorrhages. Rickettsiae bind to cholesterol-containing receptors, are endocytosed into phagolysosomes, escape into the cytosol, and multiply until they burst the cells. Rickettsiae have an endotoxin but lack secreted toxins. In addition, R. rickettsii activate host kallikrein and kinins and cause local clotting.</spoiler>
 {{IPLab 9}}
 [[Category: IPLab:Lab 9]]