IPLab:Lab 8:HSV Encephalitis - Revision history

Seung Park at 16:28, 3 January 2014

2014-01-03T16:28:22Z

Seung Park: /* Images */

2013-08-30T01:42:08Z

‎Images

Seung Park: /* Clinical Summary */

2013-08-26T00:51:10Z

‎Clinical Summary

Seung Park: /* Related IPLab Cases */

2013-08-24T01:10:40Z

‎Related IPLab Cases

Seung Park: /* Images */

2013-08-24T01:10:17Z

‎Images

Seung Park: /* Journal Articles */

2013-08-24T01:09:22Z

‎Journal Articles

Seung Park: /* Journal Articles */

2013-08-24T01:08:43Z

‎Journal Articles

Seung Park: /* Reference */

2013-08-24T01:07:42Z

‎Reference

Seung Park at 04:22, 23 August 2013

2013-08-23T04:22:31Z

Seung Park at 15:45, 21 August 2013

2013-08-21T15:45:36Z

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 IPLab8HSVEncephalitis12.jpg|This is a photomicrograph of a brain section stained with an antibody against herpes simplex. Even at this magnification, it is easy to pick out cells that are positive for the virus (arrows).
 </gallery>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/127-herpes PEIR Digital Library: Herpes Images]
+* [{{SERVER}}/library/index.php?/tags/127-herpes PEIR Digital Library: Herpes Images]
 * [http://library.med.utah.edu/WebPath/CNSHTML/CNSIDX.html#6 WebPath: CNS Infections]

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 == Clinical Summary ==
-This 30-year-old white male experienced a generalized tonic-clonic seizure and was subsequently started on a course of Dilantin. He did well, but later developed a headache lasting over a week, which was associated with tonic-clonic seizures, fever, and--toward the end of this period--ataxia. The patient improved and returned to work, but the headache returned. A lumbar puncture was then performed which showed 22 cells/cmm (all lymphocytes), protein of 88 grams/L, and a glucose level of 49 mg/dL (with a simultaneous serum glucose of 83 mg/dL). These findings were compatible with a viral infection. Despite therapy, the patient had another seizure and again developed fever. At that time, a brain biopsy was performed which showed herpetic encephalitis. Despite aggressive antiviral therapy the patient died.
+This 30-year-old white male experienced a generalized tonic-clonic seizure and was subsequently started on a course of Dilantin. He did well, but later developed a headache lasting over a week, which was associated with tonic-clonic seizures, fever, and--toward the end of this period--ataxia. The patient improved and returned to work, but the headache returned. A lumbar puncture was then performed which showed 22 cells/mm³ (all lymphocytes), protein of 88 grams/L, and a glucose level of 49 mg/dL (with a simultaneous serum glucose of 83 mg/dL). These findings were compatible with a viral infection. Despite therapy, the patient had another seizure and again developed fever. At that time, a brain biopsy was performed which showed herpetic encephalitis. Despite aggressive antiviral therapy the patient died.
 == Images ==

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 == Related IPLab Cases ==
+* [[IPLab:Lab 8:HSV Glossitis|Lab 8: Herpes Glossitis]]
 {{IPLab 8}}
 [[Category: IPLab:Lab 8]]

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 === Images ===
+* [http://peir.path.uab.edu/library/index.php?/tags/127-herpes PEIR Digital Library: Herpes Images]
 == Related IPLab Cases ==

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 === Journal Articles ===
 * Edlow JA, Panagos PD, Godwin SA, Thomas TL, Decker WW; American College of Emergency Physicians.  [http://www.ncbi.nlm.nih.gov/pubmed/18809105 Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with acute headache].  ''Ann Emerg Med'' 2008 Oct;52(4):407-36.
 === Images ===

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/218580-overview eMedicine Medical Library: Herpes Simplex]
 === Journal Articles ===

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 * <spoiler text="What age groups are susceptible to herpetic encephalitis?">HSV-1 (labialis) produces encephalitis in any age group but is most common in children and young adults. Only about 10% of the patients have a history of prior labial herpes.</spoiler>
 * <spoiler text="What type of injury is produced by herpetic encephalitis, what areas of the brain are affected, and what are the most common clinical presenting signs/symptoms?">Encephalitis usually involves the inferior and medial regions of the temporal lobes and the orbital gyri of the frontal lobes. The infection is grossly necrotizing and often hemorrhagic with perivascular inflammatory infiltrates and Cowdry intranuclear viral inclusion bodies in both neurons and glia. The most commonly observed clinical presenting symptoms are alterations in mood, memory, and behavior.</spoiler>
 {{IPLab 8}}
 [[Category: IPLab:Lab 8]]