IPLab:Lab 7:Osteosarcoma - Revision history

Peter Anderson: /* Images */

2020-07-09T21:07:37Z

‎Images

Peter Anderson: /* Autopsy Findings */

2020-07-09T20:49:04Z

‎Autopsy Findings

Peter Anderson: /* Clinical Summary */

2020-07-09T20:48:53Z

‎Clinical Summary

Seung Park at 16:26, 3 January 2014

2014-01-03T16:26:57Z

Seung Park: /* Images */

2013-08-30T01:41:28Z

‎Images

Seung Park: /* Related IPLab Cases */

2013-08-23T20:09:57Z

‎Related IPLab Cases

Seung Park: /* Images */

2013-08-23T20:09:42Z

‎Images

Seung Park: /* Images */

2013-08-23T20:08:45Z

‎Images

Seung Park: /* Journal Articles */

2013-08-23T20:06:58Z

‎Journal Articles

Seung Park: /* Reference */

2013-08-23T20:05:25Z

‎Reference

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 File:IPLab7Osteosarcoma5.jpg|These are cut sections of the distal femur containing the tumor. The periosteal involvement is evident from this picture (arrows).
 File:IPLab7Osteosarcoma6.jpg|This is a low-power photomicrograph of decalcified histologic section from this tumor. Note the blue color (cell nuclei stain blue) of much of this section indicating the increased cellularity of the tumor.
-File:IPLab7Osteosarcoma7.jpg|This is a higher-power photomicrograph of decalcified histologic section from this tumor. There are areas of osteoid (1) and cellular areas (2).
+File:IPLab7Osteosarcoma7b.jpg|This is a photomicrograph of a decalcified histologic section from normal bone. Compare this normal morphology to the subsequent images of bone in this case of osteosarcoma.
-File:IPLab7Osteosarcoma8.jpg|This is a high-power photomicrograph of decalcified histologic section showing the cellularity of the tumor.
+File:IPLab7Osteosarcoma8b.jpg|This is a higher-power photomicrograph of decalcified histologic section from this tumor. There are areas of osteoid (1) and cellular areas (2).
-File:IPLab7Osteosarcoma9.jpg|This high-power photomicrograph demonstrates the cellular growth pattern. Note that the cells are fusiform and they grow in sheets.
+File:IPLab7Osteosarcoma9b.jpg|This is a higher-power photomicrograph of decalcified histologic section showing the cellularity of the tumor.
-File:IPLab7Osteosarcoma10.jpg|This high-power photomicrograph demonstrates the growth pattern and the cell morphology.
+File:IPLab7Osteosarcoma10b.jpg|This higher-power photomicrograph demonstrates the cellular growth pattern. Note that the cells are pleomorphic and anaplastic.
-File:IPLab7Osteosarcoma11.jpg|This is a high-power photomicrograph of the tumor cell morphology and the periosteum (arrow).
+File:IPLab7Osteosarcoma11b.jpg|This high-power photomicrograph demonstrates the anaplastic cell morphology.
-File:IPLab7Osteosarcoma12.jpg|This high-power photomicrograph of the tumor demonstrates the fusiform morphology of the cells. Note the marked variability in size and staining intensity of the nuclei.
+File:IPLab7Osteosarcoma12b.jpg|This is a high-power photomicrograph of the tumor demonstrating the anaplastic cell morphology and mitotic figures (arrows).
 </gallery>

← Older revision		Revision as of 20:49, 9 July 2020
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	The distal diaphysis of the femur and adjacent soft tissues were involved in a 15 x 10 x 10-cm mass. The cut surface of the mass was fleshy white, with focal areas of hemorrhage.		The distal diaphysis of the femur and adjacent soft tissues were involved in a 15 x 10 x 10-cm mass. The cut surface of the mass was fleshy white, with focal areas of hemorrhage.
−
−	~~== Autopsy Findings ==~~
−	~~The distal diaphysis of the femur and adjacent soft tissues were involved in a 15 x 10 x 10-cm mass. The cut surface of the mass was fleshy white, with focal areas of hemorrhage.~~

	== Images ==		== Images ==

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 == Clinical Summary ==
-This 14-year-old white male first experienced mild pain in the left knee after playing baseball, approximately two months prior to admission. The pain persisted in an intermittent fashion, and was described as being somewhat worse at night. Approximately two weeks prior to admission, the pain increased significantly and was accompanied by marked swelling and loss of considerable motion of the knee joint. These symptoms were accompanied by a history of decreased appetite, lethargy, and a 10-pound weight loss. On physical examination, the left knee was enlarged diffusely, firm, and non-tender. Following biopsy, the patient was subjected to surgical removal of the distal femur and knee with placement of a prosthetic knee joint and bone grafts.
+This 14-year-old male first experienced mild pain in the left knee after playing baseball, approximately two months ago. The pain persisted in an intermittent fashion until approximately two weeks prior to admission, when the pain increased significantly and was accompanied by marked swelling and loss of motion. He also had decreased appetite, lethargy, and a 10-pound weight loss. On physical examination, the left knee was enlarged diffusely, firm, and non-tender. Radiographic and biopsy results confirmed a diagnosis of osteosarcoma.  The patient underwent surgical removal of the distal femur and knee with placement of a prosthetic knee joint and bone grafts.
 == Autopsy Findings ==

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 File:IPLab7Osteosarcoma15.jpg|This is a high-power photomicrograph of the tumor demonstrating the anaplastic cell morphology and multiple mitotic figures (arrows).
 </gallery>
 == Study Question ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
+* [{{SERVER}}/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
 * [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html#5 WebPath: Malignant Neoplasms -- Examples of Sarcomas]

@@ Line 42: / Line 42: @@
 * [http://peir.path.uab.edu/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
 * [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html#5 WebPath: Malignant Neoplasms -- Examples of Sarcomas]
 {{IPLab 7}}
 [[Category: IPLab:Lab 7]]

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 === Journal Articles ===
+* Wittig JC, Bickels J, Priebat D, Jelinek J, Kellar-Graney K, Shmookler B, Malawer MM.  [http://www.ncbi.nlm.nih.gov/pubmed/11925089 Osteosarcoma: a multidisciplinary approach to diagnosis and treatment].  ''Am Fam Physician'' 2002 Mar 15;65(6):1123-32.
 === Images ===

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/988516-overview eMedicine Medical Library: Pediatric Osteosarcoma]
 === Journal Articles ===