IPLab:Lab 7:Esophagus SCC - Revision history

Peter Anderson: /* Clinical Summary */

2020-07-09T01:11:08Z

Clinical Summary

← Older revision		Revision as of 20:11, 8 July 2020
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	== Clinical Summary ==		== Clinical Summary ==
	Approximately six months prior to admission, this 78-year-old male began having difficulty in swallowing solid food. This difficulty was described as a sticking of the food in his throat and was accompanied by cramping pain which could only be relieved by "coughing up" the ingested food. This dysphagia was accompanied by a twenty-pound weight loss. Following an upper GI series and endoscopic biopsy, the patient was given radiation treatment with considerable improvement. He did well for four months, after which the dysphagia and weight loss increased markedly. He refused operative intervention or further treatment and he died at home two months later.		Approximately six months prior to admission, this 78-year-old male began having difficulty in swallowing solid food. This difficulty was described as a sticking of the food in his throat and was accompanied by cramping pain which could only be relieved by "coughing up" the ingested food. This dysphagia was accompanied by a twenty-pound weight loss. Following an upper GI series and endoscopic biopsy, the patient was given radiation treatment with considerable improvement. He did well for four months, after which the dysphagia and weight loss increased markedly. He refused operative intervention or further treatment and he died at home two months later.

			An autopsy revealed a circumferential fungating mass in the distal third of the esophagus. This mass partially occluded the lumen of the esophagus.

	== Images ==		== Images ==

Peter Anderson: /* Autopsy Findings */

2020-07-09T01:10:46Z

Autopsy Findings

← Older revision		Revision as of 20:10, 8 July 2020
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	== Clinical Summary ==		== Clinical Summary ==
	Approximately six months prior to admission, this 78-year-old male began having difficulty in swallowing solid food. This difficulty was described as a sticking of the food in his throat and was accompanied by cramping pain which could only be relieved by "coughing up" the ingested food. This dysphagia was accompanied by a twenty-pound weight loss. Following an upper GI series and endoscopic biopsy, the patient was given radiation treatment with considerable improvement. He did well for four months, after which the dysphagia and weight loss increased markedly. He refused operative intervention or further treatment and he died at home two months later.		Approximately six months prior to admission, this 78-year-old male began having difficulty in swallowing solid food. This difficulty was described as a sticking of the food in his throat and was accompanied by cramping pain which could only be relieved by "coughing up" the ingested food. This dysphagia was accompanied by a twenty-pound weight loss. Following an upper GI series and endoscopic biopsy, the patient was given radiation treatment with considerable improvement. He did well for four months, after which the dysphagia and weight loss increased markedly. He refused operative intervention or further treatment and he died at home two months later.

	~~== Autopsy Findings ==~~
	~~An autopsy revealed a circumferential fungating mass in the distal third of the esophagus. This mass partially occluded the lumen of the esophagus.~~

	== Images ==		== Images ==

Peter Anderson: /* Journal Articles */

2016-09-19T16:42:05Z

Journal Articles

← Older revision		Revision as of 11:42, 19 September 2016
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	=== Journal Articles ===		=== Journal Articles ===
	* Shibata H, Matsubara O. [http://www.ncbi.nlm.nih.gov/pubmed/11472561 Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus]. ''Pathol Int'' 2001 Jul;51(7):498-503.		* Shibata H, Matsubara O. [http://www.ncbi.nlm.nih.gov/pubmed/11472561 Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus]. ''Pathol Int'' 2001 Jul;51(7):498-503.
			* Wu S, Powers S, Zhu W, Hannun YA. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836858/ Substantial contribution of extrinsic risk factors to cancer development]. ''Nature'' 2016 Jan 7; 529(7584): 43–47.

	=== Images ===		=== Images ===

Seung Park at 16:23, 3 January 2014

2014-01-03T16:23:08Z

← Older revision		Revision as of 11:23, 3 January 2014
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	File:IPLab7EsophSCC7.jpg\|This is a high-power photomicrograph of the tumor cells that have invaded the adjacent muscle tissue.		File:IPLab7EsophSCC7.jpg\|This is a high-power photomicrograph of the tumor cells that have invaded the adjacent muscle tissue.
	</gallery>		</gallery>

			== Virtual Microscopy ==
			<peir-vm>IPLab7EsophSCC</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park: /* Images */

2013-08-30T01:38:36Z

Images

← Older revision		Revision as of 20:38, 29 August 2013
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	=== Images ===		=== Images ===
	* [~~http://peir.path.uab.edu~~/library/index.php?/tags/254-squamous_cell_carcinoma PEIR Digital Library: Squamous Cell Carcinoma Images]		* [{{SERVER}}/library/index.php?/tags/254-squamous_cell_carcinoma PEIR Digital Library: Squamous Cell Carcinoma Images]
	* [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html WebPath: Neoplasia]		* [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html WebPath: Neoplasia]

Seung Park: /* Related IPLab Cases */

2013-08-23T19:25:22Z

Related IPLab Cases

← Older revision		Revision as of 14:25, 23 August 2013
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	== Related IPLab Cases ==		== Related IPLab Cases ==
	* [[IPLab:Lab 7:~~Esophagus~~ SCC\|Lab 7: ~~Esophagus~~: Squamous Cell Carcinoma]]		* [[IPLab:Lab 7:Lip SCC\|Lab 7: Lip: Squamous Cell Carcinoma]]
	* [[IPLab:Lab 7:IDC\|Lab 7: Breast: Infiltrating Ductal Carcinoma]]		* [[IPLab:Lab 7:IDC\|Lab 7: Breast: Infiltrating Ductal Carcinoma]]
	* [[IPLab:Lab 7:Bronchogenic Carcinoma\|Lab 7: Lung: Bronchogenic Carcinoma]]		* [[IPLab:Lab 7:Bronchogenic Carcinoma\|Lab 7: Lung: Bronchogenic Carcinoma]]

Seung Park: /* Journal Articles */

2013-08-23T19:25:04Z

Journal Articles

← Older revision		Revision as of 14:25, 23 August 2013
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	=== Journal Articles ===		=== Journal Articles ===
	* ~~Guenthner ST~~, ~~Hurwitz RM, Buckel LJ, Gray HR~~. [http://www.ncbi.nlm.nih.gov/pubmed/~~10459120 Cutaneous~~ squamous cell ~~carcinomas consistently show histologic evidence~~ of ~~in situ changes: a clinicopathologic correlation~~]. ''~~J Am Acad Dermatol~~'' ~~1999 Sep~~;41(~~3 Pt 1~~):~~443~~-8.		* Shibata H, Matsubara O. [http://www.ncbi.nlm.nih.gov/pubmed/11472561 Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus]. ''Pathol Int'' 2001 Jul;51(7):498-503.

	=== Images ===		=== Images ===

Seung Park: /* Related IPLab Cases */

2013-08-23T19:23:43Z

Related IPLab Cases

← Older revision		Revision as of 14:23, 23 August 2013
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	== Related IPLab Cases ==		== Related IPLab Cases ==
			* [[IPLab:Lab 7:Esophagus SCC\|Lab 7: Esophagus: Squamous Cell Carcinoma]]
			* [[IPLab:Lab 7:IDC\|Lab 7: Breast: Infiltrating Ductal Carcinoma]]
			* [[IPLab:Lab 7:Bronchogenic Carcinoma\|Lab 7: Lung: Bronchogenic Carcinoma]]
			* [[IPLab:Lab 7:Adenocarcinoma\|Lab 7: Colon: Adenocarcinoma]]
			* [[IPLab:Lab 7:Metastatic Adenocarcinoma\|Lab 7: Lung & Liver: Metastatic Adenocarcinoma]]

	{{IPLab 7}}		{{IPLab 7}}

	[[Category: IPLab:Lab 7]]		[[Category: IPLab:Lab 7]]

Seung Park: /* Additional Resources */

2013-08-23T19:23:26Z

Additional Resources

← Older revision		Revision as of 14:23, 23 August 2013
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	== Additional Resources ==		== Additional Resources ==
	=== Reference ===		=== Reference ===
			* [http://emedicine.medscape.com/article/1965430-overview eMedicine Medical Library: Head and Neck Cutaneous Squamous Cell Carcinoma]
			* [http://www.merckmanuals.com/professional/dermatologic_disorders/cancers_of_the_skin/overview_of_skin_cancer.html Merck Manual: Overview of Skin Cancer]
			* [http://www.merckmanuals.com/professional/dermatologic_disorders/cancers_of_the_skin/squamous_cell_carcinoma.html Merck Manual: Squamous Cell Carcinoma]

	=== Journal Articles ===		=== Journal Articles ===
			* Guenthner ST, Hurwitz RM, Buckel LJ, Gray HR. [http://www.ncbi.nlm.nih.gov/pubmed/10459120 Cutaneous squamous cell carcinomas consistently show histologic evidence of in situ changes: a clinicopathologic correlation]. ''J Am Acad Dermatol'' 1999 Sep;41(3 Pt 1):443-8.

	=== Images ===		=== Images ===
			* [http://peir.path.uab.edu/library/index.php?/tags/254-squamous_cell_carcinoma PEIR Digital Library: Squamous Cell Carcinoma Images]
			* [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html WebPath: Neoplasia]

	== Related IPLab Cases ==		== Related IPLab Cases ==

Seung Park at 04:20, 23 August 2013

2013-08-23T04:20:51Z

← Older revision		Revision as of 23:20, 22 August 2013
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	* genetic (racial) predisposition.</spoiler>		* genetic (racial) predisposition.</spoiler>
	* <spoiler text="What factors facilitate growth and spread of this tumor?">The rich lymphatic network in the submucosa of the esophagus promotes extensive circumferential and longitudinal spread. Intramural tumor cell clusters are often seen several centimeters away from the main tumor mass. Local extension into adjacent mediastinal structures occurs early and often in this disease and seriously limits the chance of curative resection.</spoiler>		* <spoiler text="What factors facilitate growth and spread of this tumor?">The rich lymphatic network in the submucosa of the esophagus promotes extensive circumferential and longitudinal spread. Intramural tumor cell clusters are often seen several centimeters away from the main tumor mass. Local extension into adjacent mediastinal structures occurs early and often in this disease and seriously limits the chance of curative resection.</spoiler>

			== Additional Resources ==
			=== Reference ===


			=== Journal Articles ===


			=== Images ===


			== Related IPLab Cases ==


	{{IPLab 7}}		{{IPLab 7}}

	[[Category: IPLab:Lab 7]]		[[Category: IPLab:Lab 7]]