IPLab:Lab 6:Amyloidosis - Revision history

Peter Anderson: /* Images */

2020-07-09T00:22:34Z

‎Images

2020-07-09T00:11:45Z

‎Autopsy Findings

2020-07-09T00:11:39Z

‎Clinical Summary

2015-09-16T19:23:31Z

‎Virtual Microscopy

2014-01-03T16:21:10Z

‎Virtual Microscopy

2014-01-03T16:20:36Z

2013-08-30T01:36:57Z

‎Images

2013-08-23T04:11:45Z

2013-08-21T15:52:33Z

2013-08-21T15:49:11Z

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 File:IPLab6Amyloid6.jpg|This is a low-power photomicrograph of liver tissue stained with Congo red (orange color in slide). Congo red reacts with amyloid and gives it an orange color (arrows).
 File:IPLab6Amyloid7.jpg|This is a high-power view of liver tissue stained with Congo red. The orange amyloid material (arrows) is seen clearly between liver parenchymal cells.
 File:IPLab6Amyloid8.jpg|This is a photomicrograph of Congo-red-stained liver tissue viewed with partially polarized light. Although not well demonstrated in this image, Congo-red-stained amyloid viewed through polarized light should give off a classic “apple green” birefringence (arrows).
 File:IPLab6Amyloid9.jpg|This is a gross photograph of kidney from this case. Note the pale yellow material within the cortex (arrows). This is indicative of amyloid within the cortex and the glomeruli. Also note that there are multiple red spots in the cortex. These represent congested glomeruli due to the vascular compromise produced by the amyloid.
 File:IPLab6Amyloid10.jpg|This photomicrograph of kidney demonstrates the amyloid deposits (arrows) within glomeruli.

← Older revision		Revision as of 00:11, 9 July 2020
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	At autopsy the liver weighed 2600 grams. It was yellowish-tan in color and cut with difficulty (fibrosis?). No other pathological changes were noted except for pneumonia and lung abscesses.		At autopsy the liver weighed 2600 grams. It was yellowish-tan in color and cut with difficulty (fibrosis?). No other pathological changes were noted except for pneumonia and lung abscesses.
−
−	~~== Autopsy Findings ==~~
−	~~The liver weighed 2600 grams. It was yellowish-tan in color and cut with difficulty (fibrosis?). No other pathological changes were noted except for pneumonia and lung abscesses.~~

	== Images ==		== Images ==

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 == Clinical Summary ==
-This 46-year-old white male with a long-standing history of rheumatoid arthritis was admitted for treatment of pneumonia. Subsequently, complications associated with lung abscesses, empyema, and septicemia led to the patient's death.
+This 46-year-old male with a long-standing history of rheumatoid arthritis was admitted for treatment of pneumonia. Subsequently, complications associated with lung abscesses, empyema, and septicemia led to the patient's death.
 == Autopsy Findings ==

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 == Virtual Microscopy ==
-=== H&E ===
+=== Liver: Amyloid H&E ===
 <peir-vm>IPLab6Amyloid_HE</peir-vm>
-=== Congo Red ===
+=== Liver: Amyloid Congo Red ===
 <peir-vm>IPLab6Amyloid_Congo_Red</peir-vm>
 == Study Questions ==

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 == Virtual Microscopy ==
-<peir-vm>IPLab6Amyloid</peir-vm>
+=== H&E ===
 == Study Questions ==

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 File:IPLab6Amyloid11.jpg|This photomicrograph of the tongue demonstrates extensive amyloid deposits (1) separating the skeletal muscle fibers of the tongue. In many cases the amyloid encircles the muscle fibers (2) and these muscle fibers are atrophied.
 </gallery>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/65-amyloidosis PEIR Digital Library: Amyloidosis Images]
+* [{{SERVER}}/library/index.php?/tags/65-amyloidosis PEIR Digital Library: Amyloidosis Images]
 * [http://library.med.utah.edu/WebPath/CINJHTML/CINJIDX.html#4 WebPath: Cellular Accumulations]

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 * <spoiler text="Is amyloid intracellular or extracellular?">Extracellular.</spoiler>
 * <spoiler text="What other organs/tissues may be affected in patients with this type of amyloidosis?">Kidneys, heart, gastrointestinal tract, and tongue.</spoiler>
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]