IPLab:Lab 5:Nodular Intercapillary Glomerulosclerosis - Revision history

Peter Anderson: /* Images */

2020-07-08T20:03:35Z

Images

← Older revision		Revision as of 15:03, 8 July 2020
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	File:IPLab5DM4b.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).		File:IPLab5DM4b.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).
	File:IPLab5DM5b.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).		File:IPLab5DM5b.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).
	File:IPLab5DM6b.~~jpg~~\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.		File:IPLab5DM6b.JPG\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.
	File:IPLab5DM7b.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.		File:IPLab5DM7b.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.
	</gallery>		</gallery>

Peter Anderson: /* Images */

2020-07-08T20:02:41Z

Images

← Older revision		Revision as of 15:02, 8 July 2020
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	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">
	File:IPLab5DM1.jpg\|This is a gross photograph of the kidneys from this case. Note that there are multiple shrunken regions (old infarcts) (arrows) and the kidneys have a rough granular appearance on the surface, which is caused by multiple small infarcts of small vessels throughout the cortex.		File:IPLab5DM1.jpg\|This is a gross photograph of the kidneys from this case. Note that there are multiple shrunken regions (old infarcts) (arrows) and the kidneys have a rough granular appearance on the surface, which is caused by multiple small infarcts of small vessels throughout the cortex.
	File:~~IPLab5DM2~~.jpg\|This is a low-power photomicrograph of the kidney from this patient. The section extends from cortex (1) to the medulla (2).		File:IPLab5DM2b.jpg\|This is a low-power photomicrograph of the kidney from this patient. The section extends from cortex (1) to the medulla (2).
	File:~~IPLab5DM3~~.jpg\|This is a higher-power photomicrograph of the cortical region. In this region there is ischemic obsolescence of glomeruli and one glomerulus with nodular glomerulosclerosis (1). Also note the thickened walls of the blood vessels (2).		File:IPLab5DM3b.jpg\|This is a higher-power photomicrograph of the cortical region. In this region there is ischemic obsolescence of glomeruli and one glomerulus with nodular glomerulosclerosis (1). Also note the thickened walls of the blood vessels (2).
	File:~~IPLab5DM4~~.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).		File:IPLab5DM4b.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).
	File:~~IPLab5DM5~~.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).		File:IPLab5DM5b.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).
	File:~~IPLab5DM6~~.jpg\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.		File:IPLab5DM6b.jpg\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.
	File:~~IPLab5DM7~~.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.		File:IPLab5DM7b.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.
	</gallery>		</gallery>

Peter Anderson: /* Autopsy Findings */

2020-07-08T19:56:10Z

Autopsy Findings

← Older revision		Revision as of 14:56, 8 July 2020
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	The autopsy showed concentric left ventricular hypertrophy, an acute myocardial infarction, and a right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were large, weighing 220 and 240 grams respectively, and had a rough surface, a few cortical scars, and blurring of the corticomedullary junctions.		The autopsy showed concentric left ventricular hypertrophy, an acute myocardial infarction, and a right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were large, weighing 220 and 240 grams respectively, and had a rough surface, a few cortical scars, and blurring of the corticomedullary junctions.

	~~== Autopsy Findings ==~~
	The autopsy showed the expected left ventricular hypertrophy, a large acute myocardial infarction, and a large right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were slightly enlarged, weighing 220 and 240 grams respectively, and had rough surfaces, a few cortical scars, and blurring of the corticomedullary junctions.

	== Images ==		== Images ==

Peter Anderson: /* Clinical Summary */

2020-07-08T19:56:00Z

Clinical Summary

← Older revision		Revision as of 14:56, 8 July 2020
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	== Clinical Summary ==		== Clinical Summary ==
	This 57-year-old white male with a 25-year history of Type I diabetes mellitus ~~(insulin-dependent )~~ developed an acute myocardial infarction followed by cerebral infarction, pulmonary dysfunction, and renal failure. There was a history of hypertension and ~~proteinuria. Laboratory findings included a~~ BUN and creatinine of ~~69 mg/dL~~ and 3.~~3 mg/dL which subsequently rose to 113~~ and 4.8, respectively~~. He subsequently died~~ of ~~multisystem failure~~.		This 57-year-old white male with a 25-year history of Type 1 diabetes mellitus developed an acute myocardial infarction followed by cerebral infarction, pulmonary dysfunction, and renal failure. There was a history of hypertension, proteinuria, and elevations in BUN and creatinine. He subsequently died of multisystem failure.

			The autopsy showed concentric left ventricular hypertrophy, an acute myocardial infarction, and a right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were large, weighing 220 and 240 grams respectively, and had a rough surface, a few cortical scars, and blurring of the corticomedullary junctions.

	== Autopsy Findings ==		== Autopsy Findings ==

Peter Anderson: /* Journal Articles */

2016-08-25T14:34:22Z

Journal Articles

← Older revision		Revision as of 09:34, 25 August 2016
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	* Herzenberg AM, Holden JK, Singh S, Magil AB. [http://www.ncbi.nlm.nih.gov/pubmed/10469869 Idiopathic nodular glomerulosclerosis]. ''Am J Kidney Dis'' 1999 Sep;34(3):560-4.		* Herzenberg AM, Holden JK, Singh S, Magil AB. [http://www.ncbi.nlm.nih.gov/pubmed/10469869 Idiopathic nodular glomerulosclerosis]. ''Am J Kidney Dis'' 1999 Sep;34(3):560-4.
	* Vinik AI. [http://www.nejm.org/doi/full/10.1056/NEJMcp1503948 Diabetic Sensory and Motor Neuropathy]. ''N Engl J Med" 2016 April 14; 374:1455-1464.		* Vinik AI. [http://www.nejm.org/doi/full/10.1056/NEJMcp1503948 Diabetic Sensory and Motor Neuropathy]. ''N Engl J Med" 2016 April 14; 374:1455-1464.
			* Kamel KS and Halperin ML. [http://www.nejm.org/doi/full/10.1056/NEJMra1207788 Acid–Base Problems in Diabetic Ketoacidosis]. ''N Engl J Med" 2015 Feb 5;372:546-554.

	=== Images ===		=== Images ===

Peter Anderson: /* Journal Articles */

2016-08-25T14:13:36Z

Journal Articles

← Older revision		Revision as of 09:13, 25 August 2016
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	=== Journal Articles ===		=== Journal Articles ===
	* Herzenberg AM, Holden JK, Singh S, Magil AB. [http://www.ncbi.nlm.nih.gov/pubmed/10469869 Idiopathic nodular glomerulosclerosis]. ''Am J Kidney Dis'' 1999 Sep;34(3):560-4.		* Herzenberg AM, Holden JK, Singh S, Magil AB. [http://www.ncbi.nlm.nih.gov/pubmed/10469869 Idiopathic nodular glomerulosclerosis]. ''Am J Kidney Dis'' 1999 Sep;34(3):560-4.
			* Vinik AI. [http://www.nejm.org/doi/full/10.1056/NEJMcp1503948 Diabetic Sensory and Motor Neuropathy]. ''N Engl J Med" 2016 April 14; 374:1455-1464.

	=== Images ===		=== Images ===

Seung Park at 16:15, 3 January 2014

2014-01-03T16:15:56Z

← Older revision		Revision as of 11:15, 3 January 2014
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	File:IPLab5DM7.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.		File:IPLab5DM7.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.
	</gallery>		</gallery>

			== Virtual Microscopy ==
			<peir-vm>IPLab5DM</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park: /* Images */

2013-08-30T01:33:42Z

Images

← Older revision		Revision as of 20:33, 29 August 2013
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	=== Images ===		=== Images ===
	* [~~http://peir.path.uab.edu~~/library/index.php?/tags/137-diabetic_glomerulosclerosis PEIR Digital Library: Diabetic Glomerulosclerosis Images]		* [{{SERVER}}/library/index.php?/tags/137-diabetic_glomerulosclerosis PEIR Digital Library: Diabetic Glomerulosclerosis Images]
	* [http://library.med.utah.edu/WebPath/RENAHTML/RENALIDX.html#3 WebPath: Interstitial Diseases of the Kidney]		* [http://library.med.utah.edu/WebPath/RENAHTML/RENALIDX.html#3 WebPath: Interstitial Diseases of the Kidney]

Peter Anderson at 16:13, 25 August 2013

2013-08-25T16:13:54Z

← Older revision		Revision as of 11:13, 25 August 2013
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	== Autopsy Findings ==		== Autopsy Findings ==
	The autopsy showed the expected left ventricular hypertrophy, a large acute myocardial infarction, and a large right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were ~~large~~, weighing 220 and 240 grams respectively, and had rough surfaces, a few cortical scars, and blurring of the corticomedullary junctions.		The autopsy showed the expected left ventricular hypertrophy, a large acute myocardial infarction, and a large right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were slightly enlarged, weighing 220 and 240 grams respectively, and had rough surfaces, a few cortical scars, and blurring of the corticomedullary junctions.

	== Images ==		== Images ==

Peter Anderson at 16:12, 25 August 2013

2013-08-25T16:12:28Z

← Older revision		Revision as of 11:12, 25 August 2013
Line 3:		Line 3:

	== Autopsy Findings ==		== Autopsy Findings ==
	The autopsy showed the expected left ventricular hypertrophy, a large acute myocardial infarction, and a large right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were large, weighing 220 and 240 grams respectively, and had ~~smooth glistening~~ surfaces, a few cortical scars, and blurring of the corticomedullary junctions.		The autopsy showed the expected left ventricular hypertrophy, a large acute myocardial infarction, and a large right cerebral infarction. The pancreas showed amyloidosis of the islets. There was extensive atherosclerosis and arteriolosclerosis. The kidneys were large, weighing 220 and 240 grams respectively, and had rough surfaces, a few cortical scars, and blurring of the corticomedullary junctions.

	== Images ==		== Images ==

← Older revision		Revision as of 15:03, 8 July 2020
Line 11:		Line 11:
	File:IPLab5DM4b.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).		File:IPLab5DM4b.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).
	File:IPLab5DM5b.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).		File:IPLab5DM5b.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).
	File:IPLab5DM6b.~~jpg~~\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.		File:IPLab5DM6b.JPG\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.
	File:IPLab5DM7b.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.		File:IPLab5DM7b.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.
	</gallery>		</gallery>

← Older revision		Revision as of 15:02, 8 July 2020
Line 7:		Line 7:
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">
	File:IPLab5DM1.jpg\|This is a gross photograph of the kidneys from this case. Note that there are multiple shrunken regions (old infarcts) (arrows) and the kidneys have a rough granular appearance on the surface, which is caused by multiple small infarcts of small vessels throughout the cortex.		File:IPLab5DM1.jpg\|This is a gross photograph of the kidneys from this case. Note that there are multiple shrunken regions (old infarcts) (arrows) and the kidneys have a rough granular appearance on the surface, which is caused by multiple small infarcts of small vessels throughout the cortex.
	File:~~IPLab5DM2~~.jpg\|This is a low-power photomicrograph of the kidney from this patient. The section extends from cortex (1) to the medulla (2).		File:IPLab5DM2b.jpg\|This is a low-power photomicrograph of the kidney from this patient. The section extends from cortex (1) to the medulla (2).
	File:~~IPLab5DM3~~.jpg\|This is a higher-power photomicrograph of the cortical region. In this region there is ischemic obsolescence of glomeruli and one glomerulus with nodular glomerulosclerosis (1). Also note the thickened walls of the blood vessels (2).		File:IPLab5DM3b.jpg\|This is a higher-power photomicrograph of the cortical region. In this region there is ischemic obsolescence of glomeruli and one glomerulus with nodular glomerulosclerosis (1). Also note the thickened walls of the blood vessels (2).
	File:~~IPLab5DM4~~.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).		File:IPLab5DM4b.jpg\|This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).
	File:~~IPLab5DM5~~.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).		File:IPLab5DM5b.jpg\|This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).
	File:~~IPLab5DM6~~.jpg\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.		File:IPLab5DM6b.jpg\|This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.
	File:~~IPLab5DM7~~.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.		File:IPLab5DM7b.jpg\|This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.
	</gallery>		</gallery>