IPLab:Lab 5:Hemochromatosis - Revision history

Peter Anderson: /* Images */

2020-07-08T19:49:18Z

‎Images

Peter Anderson: /* Autopsy Findings */

2020-07-08T19:47:47Z

‎Autopsy Findings

Peter Anderson: /* Clinical Summary */

2020-07-08T19:47:39Z

‎Clinical Summary

Peter Anderson: /* Journal Articles */

2016-04-21T18:15:46Z

‎Journal Articles

Peter Anderson: /* H&E */

2015-09-16T19:21:22Z

‎H&E

Seung Park at 16:14, 3 January 2014

2014-01-03T16:14:39Z

Seung Park: /* Images */

2013-08-30T01:33:08Z

‎Images

Peter Anderson at 15:47, 25 August 2013

2013-08-25T15:47:24Z

Peter Anderson at 15:43, 25 August 2013

2013-08-25T15:43:49Z

Seung Park: /* Images */

2013-08-22T20:38:43Z

‎Images

@@ Line 6: / Line 6: @@
 == Images ==
 <gallery heights="250px" widths="250px">
-File:IPLab5Hemochromatosis1.jpg|This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosis. Note that both of these organs have a dark brown coloration.
+File:IPLab5Hemochromatosis1b.jpg|This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosis. Note that both of these organs have a dark brown coloration.
-File:IPLab5Hemochromatosis2.jpg|This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown. Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic).
+File:IPLab5Hemochromatosis2b.jpg|This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown. Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic).
-File:IPLab5Hemochromatosis3.jpg|This is a low-power micrograph of liver from this patient. Note the nodularity of the tissue (arrows).
+File:IPLab5Hemochromatosis3b.jpg|This is a low-power micrograph of liver from this patient. Note the nodularity of the tissue (arrows).
 File:IPLab5Hemochromatosis4.jpg|This higher-power view of liver from this case demonstrates the nodules and the brown/black pigment within liver parenchymal cells (arrows).
 File:IPLab5Hemochromatosis5.jpg|This higher-power photomicrograph demonstrates the increased fibrosis in the periportal area (1) and the pigment accumulation (2).
 File:IPLab5Hemochromatosis6.jpg|This trichrome stain of liver section demonstrates the increased fibrous connective tissue in this liver. Note that the liver nodules (1) are surrounded by fibrous connective tissue (2).
-File:IPLab5Hemochromatosis7.jpg|This is a low-power view of liver section stained with Prussian blue. Prussian blue reacts with iron in the tissue to give a blue color.
+File:IPLab5Hemochromatosis7b.jpg|This is a low-power view of liver section stained with Prussian blue. Prussian blue reacts with iron in the tissue to give a blue color.
 File:IPLab5Hemochromatosis8.jpg|This higher-power view of liver stained with Prussian blue demonstrates the marked accumulation of iron within the parenchymal cells (1) and in the Kupffer cells in the periportal area (2).
 File:IPLab5Hemochromatosis9.jpg|This is a gross picture of pancreas from this case. Note the brown discoloration of the tissue.

← Older revision		Revision as of 19:47, 8 July 2020
Line 3:		Line 3:

	At autopsy the liver weighed 800 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.		At autopsy the liver weighed 800 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.
−
−	~~== Autopsy Findings ==~~
−	~~The liver weighed 820 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.~~

	== Images ==		== Images ==

@@ Line 1: / Line 1: @@
 == Clinical Summary ==
-This 61-year-old female was first admitted to the hospital because of ascites and pedal edema. A liver biopsy revealed a marked intracellular accumulation of iron. The serum iron concentration was reported as 220 mcg/dL. On the basis of these studies, the diagnosis of hemochromatosis was made. It should be noted that the patient also exhibited an abnormal glucose tolerance test at this time (following the ingestion of a test dose of glucose, the blood glucose level rose to 290 mg/dL at one hour and remained at this level for the next three hours). Subsequent to the first admission, the patient was admitted on several occasions for ascites. The patient's last admission was necessitated by the development of symptoms and signs of hepatic failure (hepatic coma) characterized by jaundice and coma.
+This 61-year-old female was first admitted to the hospital because of ascites and pedal edema.  A liver biopsy revealed a marked intracellular accumulation of iron. The serum iron concentration was increased at 220 mcg/dL. On the basis of these studies, the diagnosis of hemochromatosis was made. Subsequent to the first admission, the patient was admitted on several occasions for ascites. The patient's last admission was necessitated by the development of symptoms and signs of hepatic failure characterized by jaundice and coma.
 == Autopsy Findings ==

@@ Line 46: / Line 46: @@
 === Journal Articles ===
 * Ayonrinde OT, Milward EA, Chua AC, Trinder D, Olynyk JK.  [http://www.ncbi.nlm.nih.gov/pubmed/18712630 Clinical perspectives on hereditary hemochromatosis].  ''Crit Rev Clin Lab Sci'' 2008;45(5):451-84.
 * Bassett ML.  [http://www.ncbi.nlm.nih.gov/pubmed/11456037 Haemochromatosis: iron still matters].  ''Intern Med J'' 2001 May-Jun;31(4):237-42.

@@ Line 22: / Line 22: @@
 == Virtual Microscopy ==
 === H&E ===
 <peir-vm>IPLab5Hemochromatosis_HE</peir-vm>
 === Prussian Blue ===

@@ Line 19: / Line 19: @@
 File:IPLab5Hemochromatosis11.jpg|This is a histologic section of pancreas from this case stained for iron (Prussian blue). Note the accumulation of iron in the parenchymal cells (1). There is also iron in the pancreatic islets (2).
 </gallery>
 == Study Questions ==

@@ Line 39: / Line 39: @@
 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/177-hemochromatosis PEIR Digital Library: Hemochromatosis Images]
+* [{{SERVER}}/library/index.php?/tags/177-hemochromatosis PEIR Digital Library: Hemochromatosis Images]
 * [http://library.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html#3 WebPath: Hepatic Pigmentary Disorders]
 * [http://library.med.utah.edu/WebPath/CINJHTML/CINJIDX.html#5 WebPath: Cellular Accumulations]

@@ Line 3: / Line 3: @@
 == Autopsy Findings ==
-The liver weighed 800 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.
+The liver weighed 820 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.
 == Images ==