IPLab:Lab 2:Fatty Change and Cirrhosis - Revision history

Peter Anderson: /* Images */

2020-06-19T20:56:48Z

Images

← Older revision		Revision as of 15:56, 19 June 2020
Line 8:		Line 8:
	File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.		File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.
	File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.		File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.
	File:~~IPLab2FattyChange3~~.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (arrow) around portal tracts.		File:IPLab2FattyChange3b.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (arrow) around portal tracts.
	File:~~IPLab2FattyChange4~~.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (arrow) around the portal areas.		File:IPLab2FattyChange4b.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (arrow) around the portal areas.
	File:~~IPLab2FattyChange5~~.jpg\|High power view of hepatocytes with lipid vacuoles. In many cases the nucleus is displaced to the periphery of the cell and the entire cytoplasm is taken up by the giant lipid vacuole.		File:IPLab2FattyChange5b.jpg\|High power view of hepatocytes with lipid vacuoles. In many cases the nucleus is displaced to the periphery of the cell and the entire cytoplasm is taken up by the giant lipid vacuole.
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.

Peter Anderson: /* Images */

2020-06-19T20:54:26Z

Images

← Older revision		Revision as of 15:54, 19 June 2020
Line 13:		Line 13:
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.
	File:~~IPLab2FattyChange10~~.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains blue (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.		File:IPLab2FattyChange10b.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains blue (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.
	File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.		File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.

Peter Anderson: /* Images */

2020-06-19T20:42:36Z

Images

← Older revision		Revision as of 15:42, 19 June 2020
Line 8:		Line 8:
	File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.		File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.
	File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.		File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.
	File:IPLab2FattyChange3.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (~~arrows~~) around portal tracts.		File:IPLab2FattyChange3.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (arrow) around portal tracts.
	File:IPLab2FattyChange4.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (~~arrows~~) around the portal areas.		File:IPLab2FattyChange4.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (arrow) around the portal areas.
	File:IPLab2FattyChange5.jpg\|~~This higher-~~power ~~photomicrograph~~ of ~~the centrilobular area gives the appearance of fatty tissue, as indicated by many empty spaces. Very few normal liver cells can be seen in this slide. A few more normal-appearing~~ hepatocytes ~~are present at the left portion of the slide (arrows)~~.		File:IPLab2FattyChange5.jpg\|High power view of hepatocytes with lipid vacuoles. In many cases the nucleus is displaced to the periphery of the cell and the entire cytoplasm is taken up by the giant lipid vacuole.
	~~File:IPLab2FattyChange6.jpg\|Another view at~~ the ~~same power illustrates~~ the ~~proliferation~~ of ~~bile ducts in~~ the ~~interlobular~~ and ~~perichordal regions (arrows).~~
	~~File:IPLab2FattyChange7.jpg\|A high-power photomicrograph of~~ the ~~liver parenchyma shows that each individual liver cell~~ is ~~filled with a large, clear droplet which represents~~ the ~~space remaining after~~ lipid was dissolved by the dehydration procedure used to embed the tissue. Note that each empty space is surrounded by a thin rim of eosinophilic cytoplasm; in many instances, the hepatocyte nucleus can be seen as well. The red body (arrow) seen within a cell in the center of the slide is an acidophilic body associated with alcoholic hepatitis.
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.
	File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains ~~green~~ (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.		File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains blue (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.
	File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.		File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.

Peter Anderson: /* Clinical Summary */

2020-06-19T20:13:36Z

Clinical Summary

← Older revision		Revision as of 15:13, 19 June 2020
Line 1:		Line 1:
	== Clinical Summary ==		== Clinical Summary ==
	This 54-year-old man with a long history of alcohol abuse disorder. Three weeks prior to his demise, the patient began an alcoholic binge. Three days prior to admission the patient developed fever and malaise and when he was brought to the hospital he was semi-comatose and had a fever of 104.5°F. Shortly after arriving at the hospital, the patient died from massive pneumonia.		This 54-year-old man with a long history of alcohol abuse disorder. Three weeks prior to his demise, the patient began an alcoholic binge. Three days prior to admission the patient developed fever and malaise and when he was brought to the hospital he was semi-comatose and had a fever of 104.5°F. Shortly after arriving at the hospital, the patient died from massive pneumonia.

	At autopsy, a necrotizing lobar pneumonia was present which contained organisms consistent with Klebsiella pneumoniae. The liver was enlarged--weighing 2700 grams--and had a yellow-orange color. The liver was firm to palpation and the cut surface had a slightly granular appearance suggestive of early cirrhosis. The pancreas showed multiple areas of fibrosis.		At autopsy, a necrotizing lobar pneumonia was present which contained organisms consistent with Klebsiella pneumoniae. The liver was enlarged--weighing 2700 grams--and had a yellow-orange color. The liver was firm to palpation and the cut surface had a slightly granular appearance suggestive of early cirrhosis. The pancreas showed multiple areas of fibrosis.

	== Images ==		== Images ==

Peter Anderson: /* Autopsy Findings */

2020-06-19T20:11:58Z

Autopsy Findings

← Older revision		Revision as of 15:11, 19 June 2020
Line 3:		Line 3:

	At autopsy, a necrotizing lobar pneumonia was present which contained organisms consistent with Klebsiella pneumoniae. The liver was enlarged--weighing 2700 grams--and had a yellow-orange color. The liver was firm to palpation and the cut surface had a slightly granular appearance suggestive of early cirrhosis. The pancreas showed multiple areas of fibrosis.		At autopsy, a necrotizing lobar pneumonia was present which contained organisms consistent with Klebsiella pneumoniae. The liver was enlarged--weighing 2700 grams--and had a yellow-orange color. The liver was firm to palpation and the cut surface had a slightly granular appearance suggestive of early cirrhosis. The pancreas showed multiple areas of fibrosis.

	~~== Autopsy Findings ==~~
	At autopsy, a necrotizing lobar pneumonia was present which contained organisms consistent with Klebsiella pneumoniae. The liver was enlarged--weighing 2700 grams--and had a yellow-orange color. The liver was firm to palpation and the cut surface had a slightly granular appearance suggestive of early cirrhosis. The pancreas showed multiple areas of fibrosis.

	== Images ==		== Images ==

Peter Anderson: /* Clinical Summary */

2020-06-19T20:11:48Z

Clinical Summary

← Older revision		Revision as of 15:11, 19 June 2020
Line 1:		Line 1:
	== Clinical Summary ==		== Clinical Summary ==
	This 54-year-old man with a long history of alcohol abuse had been admitted to the hospital numerous times for abdominal pain thought to be due to gastritis or a peptic ulcer. On several occasions his serum amylase level was elevated into the range of 300-500 u/L indicating relapsing or recurrent pancreatitis. Three weeks prior to his demise, the patient began an alcoholic binge. ~~The binge continued until three~~ days prior to the patient~~'s death at which time he~~ developed fever and malaise~~, prompting him to cease drinking. He~~ was brought to the hospital semi-comatose and ~~with~~ a fever of ~~105~~.~~4°F~~. Shortly after arriving at the hospital, the patient died from massive pneumonia.		This 54-year-old man with a long history of alcohol abuse disorder. Three weeks prior to his demise, the patient began an alcoholic binge. Three days prior to admission the patient developed fever and malaise and when he was brought to the hospital he was semi-comatose and had a fever of 104.5°F. Shortly after arriving at the hospital, the patient died from massive pneumonia.

			At autopsy, a necrotizing lobar pneumonia was present which contained organisms consistent with Klebsiella pneumoniae. The liver was enlarged--weighing 2700 grams--and had a yellow-orange color. The liver was firm to palpation and the cut surface had a slightly granular appearance suggestive of early cirrhosis. The pancreas showed multiple areas of fibrosis.

	== Autopsy Findings ==		== Autopsy Findings ==

Peter Anderson: /* Images */

2015-11-08T21:42:02Z

Images

← Older revision		Revision as of 16:42, 8 November 2015
Line 15:		Line 15:
	File:IPLab2FattyChange7.jpg\|A high-power photomicrograph of the liver parenchyma shows that each individual liver cell is filled with a large, clear droplet which represents the space remaining after lipid was dissolved by the dehydration procedure used to embed the tissue. Note that each empty space is surrounded by a thin rim of eosinophilic cytoplasm; in many instances, the hepatocyte nucleus can be seen as well. The red body (arrow) seen within a cell in the center of the slide is an acidophilic body associated with alcoholic hepatitis.		File:IPLab2FattyChange7.jpg\|A high-power photomicrograph of the liver parenchyma shows that each individual liver cell is filled with a large, clear droplet which represents the space remaining after lipid was dissolved by the dehydration procedure used to embed the tissue. Note that each empty space is surrounded by a thin rim of eosinophilic cytoplasm; in many instances, the hepatocyte nucleus can be seen as well. The red body (arrow) seen within a cell in the center of the slide is an acidophilic body associated with alcoholic hepatitis.
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (2)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (3) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.
	File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains green (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.		File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains green (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.

Peter Anderson: /* Virtual Microscopy */

2015-09-16T19:16:18Z

Virtual Microscopy

← Older revision		Revision as of 14:16, 16 September 2015
Line 22:		Line 22:

	== Virtual Microscopy ==		== Virtual Microscopy ==
			=== Liver: Fatty Change and Cirrhosis ===
	<peir-vm>IPLab2FattyChange</peir-vm>		<peir-vm>IPLab2FattyChange</peir-vm>

			=== Normal Liver ===
			<peir-vm>UAB-Histology-00149</peir-vm>

	== Study Questions ==		== Study Questions ==

Seung Park at 16:03, 3 January 2014

2014-01-03T16:03:31Z

← Older revision		Revision as of 11:03, 3 January 2014
Line 19:		Line 19:
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.
	File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.		File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.
			</gallery>

	== Virtual Microscopy ==		== Virtual Microscopy ==
	<peir-vm>IPLab2FattyChange</peir-vm>		<peir-vm>IPLab2FattyChange</peir-vm>

	~~</gallery>~~

	== Study Questions ==		== Study Questions ==

Seung Park at 16:03, 3 January 2014

2014-01-03T16:03:08Z

← Older revision		Revision as of 11:03, 3 January 2014
Line 19:		Line 19:
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.
	File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.		File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.

			== Virtual Microscopy ==
			<peir-vm>IPLab2FattyChange</peir-vm>

	</gallery>		</gallery>

← Older revision		Revision as of 15:56, 19 June 2020
Line 8:		Line 8:
	File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.		File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.
	File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.		File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.
	File:~~IPLab2FattyChange3~~.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (arrow) around portal tracts.		File:IPLab2FattyChange3b.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (arrow) around portal tracts.
	File:~~IPLab2FattyChange4~~.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (arrow) around the portal areas.		File:IPLab2FattyChange4b.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (arrow) around the portal areas.
	File:~~IPLab2FattyChange5~~.jpg\|High power view of hepatocytes with lipid vacuoles. In many cases the nucleus is displaced to the periphery of the cell and the entire cytoplasm is taken up by the giant lipid vacuole.		File:IPLab2FattyChange5b.jpg\|High power view of hepatocytes with lipid vacuoles. In many cases the nucleus is displaced to the periphery of the cell and the entire cytoplasm is taken up by the giant lipid vacuole.
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.

← Older revision		Revision as of 15:54, 19 June 2020
Line 13:		Line 13:
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.
	File:~~IPLab2FattyChange10~~.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains blue (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.		File:IPLab2FattyChange10b.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains blue (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.
	File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.		File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.

← Older revision		Revision as of 15:42, 19 June 2020
Line 8:		Line 8:
	File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.		File:IPLab2FattyChange1.jpg\|This gross photograph of liver tissue illustrates the yellowish color of the liver parenchyma. The yellow color indicates high fat content in this tissue. Compare this with the normal dark red color of liver.
	File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.		File:IPLab2FattyChange2.jpg\|This low-power photomicrograph of liver illustrates a very pale-staining section with a uniform appearance throughout the section.
	File:IPLab2FattyChange3.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (~~arrows~~) around portal tracts.		File:IPLab2FattyChange3.jpg\|Another low-power photomicrograph illustrates again the pale, washed-out appearance of this tissue. Notice the numerous holes throughout the tissue. There are accumulations of inflammatory cells (arrow) around portal tracts.
	File:IPLab2FattyChange4.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (~~arrows~~) around the portal areas.		File:IPLab2FattyChange4.jpg\|A higher-power photomicrograph illustrates more clearly the inflammatory cells (arrow) around the portal areas.
	File:IPLab2FattyChange5.jpg\|~~This higher-~~power ~~photomicrograph~~ of ~~the centrilobular area gives the appearance of fatty tissue, as indicated by many empty spaces. Very few normal liver cells can be seen in this slide. A few more normal-appearing~~ hepatocytes ~~are present at the left portion of the slide (arrows)~~.		File:IPLab2FattyChange5.jpg\|High power view of hepatocytes with lipid vacuoles. In many cases the nucleus is displaced to the periphery of the cell and the entire cytoplasm is taken up by the giant lipid vacuole.
	~~File:IPLab2FattyChange6.jpg\|Another view at~~ the ~~same power illustrates~~ the ~~proliferation~~ of ~~bile ducts in~~ the ~~interlobular~~ and ~~perichordal regions (arrows).~~
	~~File:IPLab2FattyChange7.jpg\|A high-power photomicrograph of~~ the ~~liver parenchyma shows that each individual liver cell~~ is ~~filled with a large, clear droplet which represents~~ the ~~space remaining after~~ lipid was dissolved by the dehydration procedure used to embed the tissue. Note that each empty space is surrounded by a thin rim of eosinophilic cytoplasm; in many instances, the hepatocyte nucleus can be seen as well. The red body (arrow) seen within a cell in the center of the slide is an acidophilic body associated with alcoholic hepatitis.
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.
	File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains ~~green~~ (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.		File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains blue (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.
	File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.		File:IPLab2FattyChange12.jpg\|This is a cut surface of the same tissue seen in the previous slide. Note the marked nodular pattern. The paler-staining areas between the round nodules represent fibrous connective tissue.

← Older revision		Revision as of 16:42, 8 November 2015
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	File:IPLab2FattyChange7.jpg\|A high-power photomicrograph of the liver parenchyma shows that each individual liver cell is filled with a large, clear droplet which represents the space remaining after lipid was dissolved by the dehydration procedure used to embed the tissue. Note that each empty space is surrounded by a thin rim of eosinophilic cytoplasm; in many instances, the hepatocyte nucleus can be seen as well. The red body (arrow) seen within a cell in the center of the slide is an acidophilic body associated with alcoholic hepatitis.		File:IPLab2FattyChange7.jpg\|A high-power photomicrograph of the liver parenchyma shows that each individual liver cell is filled with a large, clear droplet which represents the space remaining after lipid was dissolved by the dehydration procedure used to embed the tissue. Note that each empty space is surrounded by a thin rim of eosinophilic cytoplasm; in many instances, the hepatocyte nucleus can be seen as well. The red body (arrow) seen within a cell in the center of the slide is an acidophilic body associated with alcoholic hepatitis.
	File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.		File:IPLab2FattyChange8.jpg\|An oil red O stain for fat was performed on a frozen section of this liver tissue. The red droplets represent fat in the tissue which is typical of fatty degeneration in the liver. By using frozen sections the tissues do not have to be dehydrated through alcohol solutions and thus the fat does not get washed out.
	File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (2)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (3) that are also present in this section.		File:IPLab2FattyChange9.jpg\|This photomicrograph of the liver is from another patient with a history of alcohol use. There are some clear vacuoles indicating fat droplets (1) and there are numerous red-staining granular deposits within the cytoplasm of hepatocytes (3)this is alcoholic hyalin. Alcoholic hyalin is easily distinguished from red blood cells (2) that are also present in this section.
	File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains green (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.		File:IPLab2FattyChange10.jpg\|This is a low-power photomicrograph of liver stained with a trichrome stain. In this section, connective tissue stains green (arrows) and hepatic parenchymal cells are red. Note that many of the parenchymal cells have clear spaces indicating fatty degeneration. The proliferation of scar tissue between the liver lobules is the result of cirrhosis.
	File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.		File:IPLab2FattyChange11.jpg\|This gross photograph of liver demonstrates severe nodular cirrhosis. Note the extensive scarring of the capsule and the nodular projections of tissue through the uncut capsule in this tissue. The green color is due to the accumulation of bile pigment.