IPLab:Lab 13:Wilms Tumor - Revision history

Peter Anderson: /* Clinical Summary */

2020-07-09T21:34:33Z

‎Clinical Summary

Peter Anderson: /* Images */

2020-07-09T21:32:39Z

‎Images

Peter Anderson: /* Autopsy Findings */

2020-07-09T21:30:09Z

‎Autopsy Findings

Seung Park at 16:39, 3 January 2014

2014-01-03T16:39:57Z

Seung Park: /* Images */

2013-08-30T01:50:03Z

‎Images

Seung Park: /* Related IPLab Cases */

2013-08-26T15:47:18Z

‎Related IPLab Cases

Seung Park: /* Images */

2013-08-26T15:47:08Z

‎Images

Seung Park: /* Journal Articles */

2013-08-26T15:45:46Z

‎Journal Articles

Seung Park: /* Reference */

2013-08-26T15:44:59Z

‎Reference

Seung Park at 04:28, 23 August 2013

2013-08-23T04:28:20Z

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 == Clinical Summary ==
-The mother of this three-year-old male noticed a large mass in his abdomen. There were no other complaints. Physical examination and x-rays--including an intravenous pyelogram (IVP)--showed a large right renal mass. At surgery, a 550-gram right kidney was removed. There was no lymph node involvement, no extrarenal mass, and no involvement of the other kidney. Lung and bone x-rays showed no metastases. However, microscopic study of the surgical specimen showed infiltration by the tumor (Grade II neoplasm) which had been difficult to separate from the duodenum. The child was placed on chemotherapy. Four months after the surgery to remove the tumor, a nodule was found in the lungs. The chemotherapy was resumed but the patient died four weeks later due to complications of Gram-negative sepsis.
+The mother of this three-year-old male noticed a large mass in his abdomen. There were no other complaints. Physical examination and x-rays--including an intravenous pyelogram (IVP)--showed a large right renal mass. At surgery, a 550-gram right kidney was removed. There was no lymph node involvement, no extrarenal mass, and no involvement of the other kidney. Lung and bone x-rays showed no metastases. However, microscopic study of the surgical specimen confirmed a diagnosis of Wilms tumor and showed infiltration by the tumor (Grade II neoplasm) which had been difficult to separate from the duodenum. The child was placed on chemotherapy. Four months after the surgery to remove the tumor, a nodule was found in the lungs. The chemotherapy was resumed but the patient died four weeks later due to complications of Gram-negative sepsis.
 == Images ==

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 == Images ==
 <gallery heights="250px" widths="250px">
-File:IPLab13WT1.jpg|This is a gross photograph of a bladder (1) to which are attached a normal kidney (2) and a kidney with Wilms' tumor (3). A large mass extends from the superior pole of the affected kidney. The renal capsule can be seen extending around this tumor.
+File:IPLab13WT1.jpg|This autopsy specimen if from a similar case of a child who died of Wilms tumor.  This gross photograph shows the bladder (1) to which are attached a normal kidney (2) and a kidney with Wilms tumor (3). A large mass extends from the superior pole of the affected kidney. The renal capsule can be seen extending around this tumor.
-File:IPLab13WT2.jpg|This is a closer view of the kidney with Wilms' tumor (arrows).
+File:IPLab13WT2.jpg|This is a closer view of the kidney with Wilms tumor (arrows).
 File:IPLab13WT3.jpg|This is a gross photograph of lung from this case demonstrating the metastatic tumor nodule (arrow).
 File:IPLab13WT4.jpg|This lowest-power view shows the tumor itself; no tissue is present that can be readily identified as normal kidney. There does appear to be a capsule surrounding the tumor. Eosinophilic bands are seen surrounding basophilic islands of cells. These correspond to the two types of tissue in this tumor--the basophilic cellular component termed "blastema" can be distinguished from less cellular eosinophilic areas.

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 == Clinical Summary ==
 The mother of this three-year-old male noticed a large mass in his abdomen. There were no other complaints. Physical examination and x-rays--including an intravenous pyelogram (IVP)--showed a large right renal mass. At surgery, a 550-gram right kidney was removed. There was no lymph node involvement, no extrarenal mass, and no involvement of the other kidney. Lung and bone x-rays showed no metastases. However, microscopic study of the surgical specimen showed infiltration by the tumor (Grade II neoplasm) which had been difficult to separate from the duodenum. The child was placed on chemotherapy. Four months after the surgery to remove the tumor, a nodule was found in the lungs. The chemotherapy was resumed but the patient died four weeks later due to complications of Gram-negative sepsis.
 == Images ==

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 File:IPLab13WT10.jpg|This high-power photomicrograph shows the differences in cell morphology between the blastema (1) and the fibroblast type cells (2).
 </gallery>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/265-wilms_tumor PEIR Digital Library: Wilms Tumor Images]
+* [{{SERVER}}/library/index.php?/tags/265-wilms_tumor PEIR Digital Library: Wilms Tumor Images]
 * [http://library.med.utah.edu/WebPath/RENAHTML/RENALIDX.html#8 WebPath: Renal Neoplasms]

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 * [http://peir.path.uab.edu/library/index.php?/tags/265-wilms_tumor PEIR Digital Library: Wilms Tumor Images]
 * [http://library.med.utah.edu/WebPath/RENAHTML/RENALIDX.html#8 WebPath: Renal Neoplasms]
 {{IPLab 13}}
 [[Category: IPLab:Lab 13]]

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 === Journal Articles ===
+* Vadeyar S, Ramsay M, James D, O'Neill D.  [http://www.ncbi.nlm.nih.gov/pubmed/11084972 Prenatal diagnosis of congenital Wilms' tumor (nephroblastoma) presenting as fetal hydrops].  ''Ultrasound Obstet Gynecol'' 2000 Jul;16(1):80-3.
 === Images ===

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/453076-overview eMedicine Medical Library: Surgery for Wilms Tumor]
 === Journal Articles ===