Peter Anderson at 13:55, 8 October 2026

2026-10-08T13:55:51Z

← Older revision		Revision as of 08:55, 8 October 2026
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	'''CRP-52'''		'''CRP-52'''
	==Clinical History==		==Clinical History==
			The patient is a 66 year old male. BUN 47, creatinine 4.7.

	==Gross Description:==		==Gross Description==
			Received in Zeus fixative are two cores measuring 7 and 20 mm in length and 1 mm in diameter. These are entirely submitted for immunofluorescence. Received in Carson's fixative are four cores measuring 9, 8, 13, and 4 mm in length and mm in diameter. Three 1-mm pieces are taken for EM, and the remaining tissue is submitted for light microscopy.

	==Pathology==		==Pathology==
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	<div class="mw-collapsible-content">		<div class="mw-collapsible-content">

	==Microscopic Description:==		==Microscopic Description==
	===Light Microscopy:===		===Light Microscopy===
			The specimen consists of multiple small fragments of renal cortex that contain twenty glomeruli in the three levels. Three of these are globally sclerotic, but the remainder show good preservation with no significant mesangial expansion or hypercellularity. The glomerular basement membranes are unremarkable with the silver stain. The PASH and trichrome stains show diffuse moderate interstitial fibrosis and focal tubular atrophy. However, there is also diffuse interstitial edema with numerous mononuclear inflammatory cells. The infiltrate is composed primarily of lymphocytes with occasional plasma cells and rare eosinophils. Many examples of tubulitis are identified. Several arteries show severe intimal fibrous thickening.

	===Immunofluorescence:===		===Immunofluorescence===
			There are four glomeruli in the sections. Stains for IgG, IgM, IgA, Clq, C3, albumin and light chains are negative in the glomeruli. There is no staining of the tubular basement membranes or vessels.

	~~===Electron Microscopy:===~~

			===Electron Microscopy===
			Three thick sections containing a total of two glomeruli are available. Ultrastructural examination of one glomerulus reveals no significant mesangial expansion or hypercellularity. The glomerular basement membranes are of normal thickness, and the foot processes are intact. No electron dense deposits are identified. Numerous examples of emperipolesis are identified in the proximal tubules.

	</div></div>		</div></div>

	<spoiler text="Diagnosis and Comments">		<spoiler text="Diagnosis and Comments">
			Kidney, needle biopsy
			- Acute tubulointerstitial nephritis.

			- Severe arteriosclerosis with moderate interstitial fibrosis.

			These features are most: consistent with acute tubulointerstitial nephritis. However, there is also a background of moderately severe interstitial fibrosis, probably secondary to arteriosclerosis. Although eosinophils are relatively rare in this biopsy, this does not rule out a drug-induced allergic interstitial nephritis.
	</spoiler>		</spoiler>

Peter Anderson: Created page with "'''CRP-52''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-052 H&E=== specialcrp/CRP-052_HE ===Case CRP-052 PASH=== specialcrp/CRP-052_PASH
Microscopic Description, Immunofluorescence, and Electron Microscopy.

==M..."

2026-10-07T18:36:49Z

Created page with "'''CRP-52''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-052 H&E=== <peir-vm>specialcrp/CRP-052_HE</peir-vm> ===Case CRP-052 PASH=== <peir-vm>specialcrp/CRP-052_PASH</peir-vm> <div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer"> Microscopic Description, Immunofluorescence, and Electron Microscopy.</div> <div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-diagnosis"> <div class="mw-collapsible-content"> ==M..."

New page

'''CRP-52'''
==Clinical History==

==Gross Description:==

==Pathology==
===Case CRP-052 H&E===
<peir-vm>specialcrp/CRP-052_HE</peir-vm>
===Case CRP-052 PASH===
<peir-vm>specialcrp/CRP-052_PASH</peir-vm>

<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer"> Microscopic Description, Immunofluorescence, and Electron Microscopy.</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-diagnosis">
<div class="mw-collapsible-content">

==Microscopic Description:==
===Light Microscopy:===

===Immunofluorescence:===

===Electron Microscopy:===

</div></div>

<spoiler text="Diagnosis and Comments">

</spoiler>

CRP-52 - Revision history

Peter Anderson at 13:55, 8 October 2026

Peter Anderson: Created page with "'''CRP-52''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-052 H&E=== specialcrp/CRP-052_HE ===Case CRP-052 PASH=== specialcrp/CRP-052_PASH Microscopic Description, Immunofluorescence, and Electron Microscopy. ==M..."

Peter Anderson: Created page with "'''CRP-52''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-052 H&E=== specialcrp/CRP-052_HE ===Case CRP-052 PASH=== specialcrp/CRP-052_PASH
Microscopic Description, Immunofluorescence, and Electron Microscopy.

==M..."