CRP-42 - Revision history

Peter Anderson at 14:36, 8 October 2026

2026-10-08T14:36:07Z

← Older revision		Revision as of 09:36, 8 October 2026
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	<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer"> Microscopic Description, Immunofluorescence, and Electron Microscopy.</div>		<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer"> Microscopic Description, Immunofluorescence, and Electron Microscopy</div>
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	<div class="mw-collapsible-content">		<div class="mw-collapsible-content">

Peter Anderson at 13:29, 8 October 2026

2026-10-08T13:29:31Z

← Older revision		Revision as of 08:29, 8 October 2026
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	'''CRP-42'''		'''CRP-42'''
	==Clinical History==		==Clinical History==
			Thirteen-year-old black female with sickle cell disease, systemic lupus erythematosus and proteinuria. Percutaneous needle biopsy of the right kidney was performed.

	==Gross Description:==		==Gross Description==
			The specimen is labeled “Renal bx”. It consists of two portions of light tan tissue measuring 0 8 x 0.1 x 0.1 cm and 0.3 x 0.1 x 0.1 cm. (Jar 0)

	==Pathology==		==Pathology==
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	<div class="mw-collapsible-content">		<div class="mw-collapsible-content">

	==Microscopic Description:==		==Microscopic Description==
	===Light Microscopy:===		===Light Microscopy===
			The sections show portions of sub capsular cortex. Up to twelve glomeruli are available for examination on multiple sections. The glomeruli are enlarged and show mild segmental expansion of the mesangial matrix and segmental thickening of the peripheral capillary walls, which have a beaded appearance on trichrome and Jones silver stains. Numerous capillary loops are ectatic and contain sickled erythrocytes. No globally or segmentally sclerosed glomeruli are found. The interstitium, tubules and blood vessels are essentially unremarkable. One tubulointerstitial calcific deposit is noted. There are no detectable glomerular or tubular hemosiderin deposits. ABPASH, trichrome and Jones silver stains have appropriately reactive controls.

	===Immunofluorescence:===		===Immunofluorescence===
			One glomerulus is available for examination by immunofluorescence on sections stained with IgG, IgM, IgA, C1q and C3. There is finely granular basement membrane staining with IgM (1+) and linearly granular staining with IgA (trace). No glomerular staining is noted with IgG, C1q and C3. No glomeruli are available for examination on sections stained with C4, fibrinogen, albumin or kappa and lambda light chains.

	~~===Electron Microscopy:===~~

			===Electron Microscopy===
			Three glomeruli are present on multiple plastic-embedded BFMB-stained sections. The glomeruli are enlarged and show segmental mesangial matrix expansion and segmental thickening of the capillary walls. The capillary lumina contain sickled erythrocytes. Ultrastructural examination shows segmental thinning and segmental wrinkling of the glomerular basement membranes. There is extensive mesangial interposition and segmental accumulation of subendothelial flocculent material. The capillary lumina are ectatic and contain sickled erythrocytes. The mesangium is expanded by basement membrane-like material. There is segmental foot process obliteration of the visceral epithelial cells. Some of the visceral epithelial cells contain irregular electron dense iron deposits and ingested effete erythrocytes. No electron-dense deposits are recognized.

	</div></div>		</div></div>

	<spoiler text="Diagnosis and Comments">		<spoiler text="Diagnosis and Comments">
			Kidney, right, biopsy:
			Sickle Cell Nephropathy

			The biopsy shows light microscopy, immunofluorescence and ultrastructural features of the nephropathy of sickle cell disease. Features of systemic lupus erythematosus are not recognized.

	</spoiler>		</spoiler>

Peter Anderson: Created page with "'''CRP-42''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-042 H&E=== specialcrp/CRP-042_HE ===Case CRP-042 PASH=== specialcrp/CRP-042_PASH
Microscopic Description, Immunofluorescence, and Electron Microscopy.

==M..."

2026-10-07T18:19:58Z

Created page with "'''CRP-42''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-042 H&E=== <peir-vm>specialcrp/CRP-042_HE</peir-vm> ===Case CRP-042 PASH=== <peir-vm>specialcrp/CRP-042_PASH</peir-vm> <div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer"> Microscopic Description, Immunofluorescence, and Electron Microscopy.</div> <div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-diagnosis"> <div class="mw-collapsible-content"> ==M..."

New page

'''CRP-42'''
==Clinical History==

==Gross Description:==

==Pathology==
===Case CRP-042 H&E===
<peir-vm>specialcrp/CRP-042_HE</peir-vm>
===Case CRP-042 PASH===
<peir-vm>specialcrp/CRP-042_PASH</peir-vm>

<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer"> Microscopic Description, Immunofluorescence, and Electron Microscopy.</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-diagnosis">
<div class="mw-collapsible-content">

==Microscopic Description:==
===Light Microscopy:===

===Immunofluorescence:===

===Electron Microscopy:===

</div></div>

<spoiler text="Diagnosis and Comments">

</spoiler>

CRP-42 - Revision history

Peter Anderson at 14:36, 8 October 2026

Peter Anderson at 13:29, 8 October 2026

Peter Anderson: Created page with "'''CRP-42''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-042 H&E=== specialcrp/CRP-042_HE ===Case CRP-042 PASH=== specialcrp/CRP-042_PASH Microscopic Description, Immunofluorescence, and Electron Microscopy. ==M..."

Peter Anderson: Created page with "'''CRP-42''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-042 H&E=== specialcrp/CRP-042_HE ===Case CRP-042 PASH=== specialcrp/CRP-042_PASH
Microscopic Description, Immunofluorescence, and Electron Microscopy.

==M..."