Difference between revisions of "IPLab:Lab 5:Gout"

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== Study Questions ==
 
== Study Questions ==
* <spoiler text="What are the two types of gout and which is more common?">The main type is primary gout which makes up 90% of all cases. In most cases of primary gout the enzyme defect is unknown. In rare cases the enzyme defect is known, but gout symptomatology is the main clinical finding.
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* <spoiler text="What are the two types of gout and which is more common?">The main type is primary gout which makes up 90% of all cases. In most cases of primary gout the specific enzyme defect is unknown but there is some enzyme abnormality which leads to hyperuricemia and symptoms of gout. In about 10% of cases cases the enzyme defect is known, but gout symptomatology is the main clinical finding.
  
 
In secondary gout the cause of the hyperuricemia is known (e.g. leukemia, renal failure, Lesch-Nyhan syndrome).</spoiler>
 
In secondary gout the cause of the hyperuricemia is known (e.g. leukemia, renal failure, Lesch-Nyhan syndrome).</spoiler>

Revision as of 06:23, 5 December 2016

Contents

Clinical Summary

This patient was diagnosed with gout approximately 20 years ago. At that time, he noted the gradual onset of pain in the left knee, followed by swelling, redness and heat, all of which persisted for approximately one month. Shortly thereafter, he had periodic episodes of hot, painful, swollen joints involving the left knee, left ankle, and both first metatarsophalangeal joints. At this time the patient was hospitalized for evaluation of these arthritides. Serum uric acid values on three separate occasions were 8.0, 9.3, and 8.7 mg/dlThe normal serum uric acid level for a male is 3.9 to 8.1 mg/dl.. In addition to the presence of the painful swollen joints, a gouty tophusA tophus is a chalky accumulation of urate crystals found in the tissue surrounding a joint. was present on the left arm. The patient was readmitted to the hospital from time to time because of acute exacerbations of gouty arthritis. On the most recent hospital admission, a 3-cm tophusA tophus is a chalky accumulation of urate crystals found in the tissue surrounding a joint. was found over the right elbow, as well as several smaller tophi over the right hand.

Autopsy Findings

The specimen consisted of an elliptically shaped, mottled, yellow-white irregular hard mass, measuring 8.0 x 5.0 x 2.0 cm. in diameter.

Images

Virtual Microscopy

Study Questions


Additional Resources

Reference

Journal Articles

Images

Related IPLab Cases