IPLab:Lab 2:Fatty Change and Cirrhosis

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Clinical Summary

This 54A normal PaCO2 is 35 to 45 mmHg.-year-old man with a long history of alcohol abuse had been admitted to the hospital numerous times for abdominal pain thought to be due to gastritisGastritis is inflammation of the stomach. or a peptic ulcer. On several occasions his serum amylase level was elevated into the range of 300-500 u/LA normal serum amylase level is 30 to 110 u/L. indicating relapsing or recurrent pancreatitisChronic inflammation of the pancreas (pancreatitis) is most often caused by alcoholism or biliary tract calculi.. Three weeks prior to his demise, the patient began an alcoholic binge. The binge continued until three days prior to the patient's death at which time he developed fever and malaise, prompting him to cease drinking. He was brought to the hospital semi-comatose and with a fever of 105.4°F. Shortly after arriving at the hospital, the patient died from massive pneumoniaIn alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents..

Autopsy Findings

At autopsy, a necrotizing lobar pneumoniaNecrotizing lobar pneumonia is a severe acute pneumonia caused by virulent organisms and aspirated of gastric contents. was present which contained organisms consistent with Klebsiella pneumoniae. The liver was enlarged--weighing 2700 gramsA normal liver weighs 1650 grams (range: 1500 to 1800 grams).--and had a yellow-orange color. The liver was firm to palpation and the cut surface had a slightly granular appearance suggestive of early cirrhosisCirrhosis is a liver disease characterized by necrosis, fibrosis, loss of normal liver architecture, and hyperplastic nodules.. The pancreas showed multiple areas of fibrosis.


Virtual Microscopy

Liver: Fatty Change and Cirrhosis

Normal Liver

Study Questions

Additional Resources


Journal Articles


Related IPLab Cases