Difference between revisions of "IPLab:Lab 1:Tuberculosis"

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File:IPLab1Tuberculosis6.jpg|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.
 
File:IPLab1Tuberculosis6.jpg|This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.
 
File:IPLab1Tuberculosis7.jpg|This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
 
File:IPLab1Tuberculosis7.jpg|This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
File:IPLab1Tuberculosis8.jpg|This is a high-power photomicrograph of Langhans-type multinucleated giant cells (arrows) that are characteristic of tuberculous granulomas. Note the ring of the nuclei in these giant cells.  
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File:IPLab1Tuberculosis8b.jpg|This is a high-power photomicrograph of Langhans-type multinucleated giant cells (arrows) that are characteristic of tuberculous granulomas. Note the ring of the nuclei in these giant cells.  
 
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Latest revision as of 12:52, 31 October 2016

Contents

Clinical Summary

This 70-year-old man was admitted to the hospital with a history of upper abdominal pain, anorexia, nausea, and general malaise, all of approximately three weeks' duration. His hospital stay was characterized by fever and severe respiratory distress. There were multiple densities in the patient's chest x-ray consistent with pneumoniaIn alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents. and examination of a stained sputum specimen showed acid fast bacilliAcid fast bacilli are not easily decolorized by acid during staining. This is characteristic of mycobacteria.. Despite intensive therapy, the patient progressively deteriorated and died 14 days after admission.

Autopsy Findings

It was determined at autopsy that the patient suffered from pulmonary tuberculosis with widespread dissemination throughout the body. The left lung weighed 620 gramsA normal left lung weighs 375 grams (range: 325 to 480 grams). and the right lung 1230 gramsA normal right lung weighs 450 grams (range: 360 to 570 grams.. These were characterized by marked pulmonary congestionPulmonary congestion is the engorgement of pulmonary vessels with blood. The increased pressure caused by this engorgement leads to transudation of fluid through the capillary walls and into the alveolar and interstitial spaces. and pulmonary edemaPulmonary edema refers to the accumulation of fluid in the pulmonary alveolar and tissue spaces as a result of changes in capillary permeability and/or increases in capillary hydrostatic pressure.. In addition, multiple gray-white nodules ranging from pinpoint size up to 1 cm were diffusely distributed throughout the lung parenchyma.

Images

Virtual Microscopy

Lung: Tuberculosis

Normal Lung

Study Questions


Additional Resources

Reference

Journal Articles

Images

Related IPLab Cases