Cytologically Yours: Unknowns: 201312: Case 4

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Clinical History

25 year old female. Right breast core touch prep.


Resident Questions

Surgical Pathology

Cytologic Features

  • The distinction between and adenoma and lactational change on cytology is extremely difficult (impossible).
  • Hypercellar smears
  • Loosely cohesive fragments
  • Larger cells with prominent nucleoli
  • Vacuolated cytoplasm
  • Naked nuclei may be present in the background.
  • Dirty background with inflammatory cells, macrophages, proteinaceous debris, blood
  • May be initially confused with carcinoma.