Difference between revisions of "Cytologically Yours: CoW: 20140220"

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(Created page with "== Clinical Summary == The patient is a 58 year old male with back and neck pain. === Past Medical History === * Cervical spondylosis * Hypertension * Hyperlipidemia === Pa...")
 
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===Cytology===
 
===Cytology===
 
<gallery heights="250px" widths="250px">
 
<gallery heights="250px" widths="250px">
CytologicallyYoursCoW20140220Cytology1.jpg|40x magnification of highly atypical malignant appearing cells.
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CytologicallyYoursCoW20140220Cytology1.jpg|20x magnification of a cellular specimen with numerous follicles and absent colloid.
CytologicallyYoursCoW20140220Cytology2.jpg|20x magnification showing osteoid formation.
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CytologicallyYoursCoW20140220Cytology2.jpg|40x magnification with follicular cells forming microfollicular groups and inspissated colloid.
CytologicallyYoursCoW20140220Cytology3.jpg|40x magnification showing osteoid formation and malignant appearing cells.
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CytologicallyYoursCoW20140220Cytology3.jpg|60x magnification with follicular cells forming microfollicular groups and inspissated colloid.
CytologicallyYoursCoW20140220Cytology4.jpg|40x magnification showing osteoid formation and malignant appearing cells.
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CytologicallyYoursCoW20140220Cytology4.jpg|40x magnification with follicular cells forming microfollicular groups and inspissated colloid.
CytologicallyYoursCoW20140220Cytology5.jpg|40x magnification of osteoid.
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CytologicallyYoursCoW20140220Cytology5.jpg|40x magnification of Pap stained material showing magnification with follicular cells forming microfollicular groups and inspissated colloid..
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CytologicallyYoursCoW20140220Cytology6.jpg|60x magnification of Pap stained material with microfollicles.
  
 
</gallery>
 
</gallery>
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====Resident Questions====
 
====Resident Questions====
 
* <spoiler text="What is the differential diagnosis?"> In a cellular thyroid lesion, follicular neoplasm, including adenoma and carcinoma, and cellular benign follicular nodule are in the differential. Also in the differential is the follicular variant of papillary carcinoma.  </spoiler>
 
* <spoiler text="What is the differential diagnosis?"> In a cellular thyroid lesion, follicular neoplasm, including adenoma and carcinoma, and cellular benign follicular nodule are in the differential. Also in the differential is the follicular variant of papillary carcinoma.  </spoiler>
* <spoiler text="What are the molecular features that differentiate follicular carcinoma and papillary carcinoma?>"> Follicular carcinoma show PAX8-PPAR gamma translocations and papillary carcinoma shows BRAF mutations and RET/PTC rearrangements. </spoiler>
 
  
 
<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer">Click here to toggle the diagnosis and discussion.</div>
 
<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer">Click here to toggle the diagnosis and discussion.</div>

Revision as of 16:46, 4 March 2014

Contents

Clinical Summary

The patient is a 58 year old male with back and neck pain.

Past Medical History

  • Cervical spondylosis
  • Hypertension
  • Hyperlipidemia

Past Surgical History

  • No surgical history

Radiology

  • Ultrasound of the neck shows a solid interpolar nodule 1.8 x 1.6 cm in the left lobe of the thyroid.

Clinical Plan

Fine needle aspiration of the nodule is scheduled.

Pathology

Cytology


Resident Questions


Click here to toggle the diagnosis and discussion.

Final Diagnosis

Cytology

  • Follicular neoplasm.


Discussion

The diagnostic criteria for follicular lesions are based on cellularity and the presence of colloid. Follicular lesions will be cellular with an absence of the variability in the size of the follicular groups, with a predominately microfollicular pattern. Colloid will be scant to absent, except for the presence of inspissated colloid in the center of follicular groups. There is often a disorganized, crowded follicular pattern with some nucleomegaly and nucleoli.