Cytologically Yours: CoW: 20140113
The patient is a 69 year old female with a new mass in the right pulmonary hilum.
Past Medical History
- Chronic obstructive pulmonary disease
- Smoker (1 pack per day for 40 years, quit in 2002)
Past Surgical History
- Hysterectomy (1975)
- Hernia repair (1992)
- Cardiac catheterization (2002)
- Lumbarsacral discectomy (2008)
- Lumbarsacral fusion with rod placement (2013)
- 4.8 x 3.1 cm mass in the right hilum.
- 4.4 x 1.5 cm nodular densityin the right upper lobe.
- 1.5 cm enlarged paratracheal lymph node.
- CT with contrast: mass in the right hilum extends into the mediastium and the SVC is compressed.
Bronchoscopy for furhter evaluation.
10x magnification of a cellular specimen.(DQ)
40x magnification showing cohesive groups of atypical cells adjacent to bronchial cells. (DQ)
40x magnification showing a large group of cohesive cells that are molding upon one another. (DQ)
40x magnification showing cells that are molding and forming a row of cells.(DQ)
20x magnification of cells with chromatin that looks punctate.(pap)
60x magnification of cells with punctate chromatin and molding.(pap)
Positive for malignancy.
CD56, Synaptophysin, Chromogranin, TTF-1
- Small Cell Carcinoma.
Small cell carcinoma is associated with smoking and is generally a central lesion that arises in larger airways. Small cell carcinoma is prone to central necrosis and radiologically this may be seen.