IPLab:Lab 1:Prostate

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Clinical Summary

This 68-year-old man with a 7-year history of prostatic carcinomaProstatic carcinoma is a highly metastatic form of cancer. developed metastases to the bones of the pelvis and lumbar spine which produced significant pain and discomfortBack pain resulting from vertebral metastases of prostatic carcinoma is not uncommonly the presenting symptom which leads to the discovery of the carcinoma. Pain occurs late in the metastatic process and is an indicator of a poor outlook for a patient.. He was treated with androgen deprivation therapy to slow the growth of the tumor and decrease the size of the tumor metastases in order to help relieve his bone pain. The androgen deprivation therapy did reduce his pain; however, two months after starting the androgen deprivation therapy, the patient experienced an acute myocardial infarctionMyocardial infarction is necrosis of myocardial tissue which occurs as a result of a deprivation of blood supply, and thus oxygen, to the heart tissue. Blockage of blood supply to the myocardium is caused by occlusion of a coronary artery. and died suddenly.

Autopsy Findings

At autopsy the patient's myocardial infarctionMyocardial infarction is necrosis of myocardial tissue which occurs as a result of a deprivation of blood supply, and thus oxygen, to the heart tissue. Blockage of blood supply to the myocardium is caused by occlusion of a coronary artery. was found to have resulted from the thrombotic occlusionAn occlusion is a blockage. of the proximal left anterior descending coronary artery. There was evidence of cancer in the peripheral region of the prostate glandMost commonly, prostatic carcinoma arises in the peripheral region of the gland. and there were metastases present in the pelvis and lumbar spine. The patient also had moderate testicular atrophy.

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