Cardiovascular: Cardiovascular

AIDS | Bone | Cancer | Cardiovascular | Cell Matrix | Gene Therapy Immunology | Infectious Disease | Metabolic Disease | Neurobiology

Research focuses on cardiovascular pathology and free radical damage. UAB Cardiovascular Research and Training Center UAB Cardiovascular MRI Facility UAB Center for Wine and Cardiovascular Health UAB Atherosclerosis Research Unit UAB Cell Adhesion and Matrix Research Center   Cellular metabolism and bioenergetics are critical for a variety of cell functions, including energy production, cell growth, programmed cell death, cell signaling processes, and thermogenesis. Alterations in these processes initiate and/or contribute to various disease pathologies where oxygen utilization or deprivation is a component, such as stroke and heart disease.  Typical student projects involve understanding how mitochondrial DNA or proteins become damaged during the initiation and development of disease.   Signal transduction is the process through which cells communicate with each other and their environment.  The program has a broad range of expertise in this area investigating the mechanisms of cell death and survival. Typical student projects encompass areas of cardiovascular and cancer to define the mechanisms of free radical and cytokine signaling during pathogenesis.   Cell adhesion and migration are involved in the development and function of almost every organ, and are essential for blood pressure maintenance, bone remodeling, nerve network building, and tumor metastasis. Typical student projects investigate the mechanisms involved in abnormal adhesion and migration that contribute to pathological states of different diseases.   Inflammation plays a central role in the development of a wide variety of cardiovascular related diseases. The program utilizes state-of-the art methodology to define the  molecular mechanisms through which inflammation modulates disease. Typical student projects include understanding cell signaling during inflammation and how cells interact with each other and their environment in the context of sepsis, cancer, diabetes and atherosclerosis   Diabetes is a complex metabolic derangement characterized by increased blood glucose concentrations and an absolute or relative decrease in insulin, typically combined with tissue insulin resistance.  Student projects include studies on insulin signaling and gene expression in diabetes and in multiple other insulin resistant states associated with diseases such as cardiovascular disease, trauma, and infections.   UAB Researchers Explore New Type of Implantable Heart Device UAB's Preeminent Cardiovascular Surgeon, Albert D. Pacifico, M.D., to Retire Alabama Collaboration for Cardiovascular Equality (ACCE) Dr. James K. Kirklin Named Director of UAB Cardiovascular and Thoracic Surgery Oparil Wins American Heart Association Lifetime Achievement Award NIH Gives UAB Special Valentine: Money to Fix Broken Hearts:  $18 Million Grant Funds Research Program with Focus on Heart Failure, Looks for New Treatments   Molecular & Cellular Pathology Cardiovascular Research Faculty   Anderson, Peter G., D.V.M., Ph.D. Research Focus: Cardiovascular pathology; education Select Highlights and Articles: Pathology Education Instructional Resource (PEIR) PEIR Development Awards Group for Research in Pathology Education Online Resources to Facilitate Pathology Instruction Donor PAI-1 Expression Inhibits the Intimal Response of Early Allograft Vascular Disease   Ballinger, Scott, Ph.D. Research Focus: Cardiovascular disease mediated by free radicals, mitochondrial damage, and dysfunction Select Highlights and Articles: Ballinger Joins Molecular and Cellular Pathology Mitochondrial Dysfunction in Cardiovascular Disease The Metabolic Syndrome Resulting from a Knockout of the NEIL1 DNA Glycosylase Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage Differential Effects of Exercise on Aortic Mitochondria Modification of the Mitochondrial Proteome in Response to the Stress of Ethanol-dependent Hepatotoxicity   Darley-Usmar, Victor, Ph.D. Research Focus: Mechanisms of redox signaling in cardiovascular disease Select Highlights and Articles: In Praise of Wine: The Great Protector Evidence of Cardiovascular Protection by Moderate Alcohol: Role of Nitric Oxide Cell Signalling by Oxidized Lipids and the Role of Reactive Oxygen Species in the Endothelium A Sensitive Method for the Quantitative Measurement of Protein Thiol Modification in Response to Oxidative Stress Weight Loss and Race Modulate Nitric Oxide Metabolism in Overweight Women Modification of the Mitochondrial Proteome in Response to the Stress of Ethanol-dependent Hepatotoxicity Hypoxia, Red Blood Cells, and Nitrite Regulate NO-dependent Hypoxic Vasodilation The Powerhouse Takes Control of the Cell: the Role of Mitochondria in Signal Transduction   Murphy-Ullrich, Joanne, Ph.D. Research Focus: Regulation of cell death and motility by cell adhesion signaling and role of growth factor control in diabetic and fibrotic diseases Select Highlights and Articles: Cell Adhesion and Matrix Research Center: Unraveling the Complexities of Tissue Fibrosis CAMRC Expands Translational Possibilities: FRET Microscopy Core Facility Launched  Thrombospondin I Mediates Angiotensin II Induction of TGF-Beta Activation by Cardiac and Renal Cells under Both High and Low Glucose Conditions Glutathione Restores Collagen Degradation in TGF-Beta-treated Fibroblasts by Blocking Plasminogen Activator Inhibiitor-1 Expression and Activating Plasminogen Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte Endothelin-A Receptor Blockade Prevents and Partially Reverses Neonatal Hypoxic Pulmonary Vascular Remodeling Transducible Heat Shock Protein 20 (HSP20) Phosphopeptide Alters Cytoskeletal Dynamics   Patel, Rakesh, Ph.D. Research Focus: Inflammation; free radicals; atherosclerosis; sepsis; nitric oxide; hemoglobin; antioxidants; endothelial cell biology Select Highlights and Articles: Mechanisms of Cystic Fibrosis Transmembrane Conductance Regulator Activation by S-nitrosoglutathione Metabolism of Phytoestrogen Conjugates Effects of Sodium Nitrite on Ischemia-Reperfusion Injury in the Rat Kidney Hypoxia, Red Blood Cells, and Nitrite Regulate NO-dependent Hypoxic Vasodilation Cytoprotective Effects of Nitrite During in Vivo Ischemia-Reperfusion of the Heart and Liver

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