Gene Therapy: Gene Therapy

AIDS | Bone | Cancer | Cardiovascular | Cell Matrix | Gene Therapy Immunology | Infectious Disease | Metabolic Disease | Neurobiology

Gene therapy represents a novel approach to human disease based on direct employment of nucleic acids as medicine. Gene therapy is the transfer of genetic material to the cells of an individual for therapeutic purposes. Successful human gene therapy depends on the development of gene delivery vehicles, or vectors, capable of mediating safe and efficient gene transfer to target cells. Current research investigates the use of gene therapy for inherited disorders, infectious disease, autoimmune disorders, and chronic acquired disorders, such as cancer and coronary artery disease. Typical research projects for graduate students involve designing novel vectors and testing their efficacy in animal models of human diseases. UAB Gene Therapy Center UAB Division of Human Gene Therapy UAB-pioneered Ovarian Cancer Gene Therapy UAB Treats Fourth Patient in Cardiac Gene Therapy Trial Arming Viruses to Fight Cancer: UAB Scientists Explore Potential of Virotherapy UAB Receives Brain Tumor SPORE: $11.5 Million Grant to Develop New Therapies Oral Cavity Cancer: A Multidisciplinary Approach   Molecular and Cellular Pathology Gene Therapy Research Faculty   Douglas, Joanne, Ph.D. Research Focus: Gene therapy; adenoviral vectors; conditionally replicating adenoviruses Select Highlights and Articles: New Texts for a New Discipline RhoA and Cytoskeletal Disruption Mediate Reduced Osteoblastogenesis and Enhanced Adipogenesis of Human Mesenchymal Stem Cells in Modeled Microgravity An Adenovirus Vector with a Chimeric Fiber Derived from Canine Adenovirus Type 2 Displays Novel Tropism Targeting of Adenovirus Via Genetic Modification of the Viral Capsid Combined with a Protein Bridge Retargeting of Adenoviral Infection to Melanoma: Combining Genetic Ablation of Native Tropism with a Recombinant Bispecific Single-chain Diabody (scDb) Adapter that Binds to Fiber Knob and HMWMAA   Krasnykh, Victor Ph.D. Research Focus: Gene therapy directed at tumor vasculature Select Highlights and Articles: Identification of Sites in Adenovirus Hexon for Foreign Peptide Incorporation Targeting of Adenovirus Via Genetic Modification of the Viral Capsid Combined with a Protein Bridge Promoter-controlled Infectivity-enhanced Conditionally Replicative Adenoviral Vectors for the Treatment of Gastric Cancer Adenoviruses with an RGD-4C Modification of the Fiber Knob Elicit a Neutralizing Antibody Response but Continue to Allow Enhanced Gene Delivery HSV-1 Virions Engineered for Specific Binding to Cell Surface Receptors Mode of Transgene Expressioin after Fusion to Early or Late Viral Genes of a Conditionally Replicating Adenovirus Via an Optomized Internal Ribosome Entry Site In Vitro and In Vivo   Ponnazhagan, Selvarangan, Ph.D. Research Focus: Adeno-associated virus gene therapy Select Highlights and Articles: Protein Transduction of Dendritic Cells for NY-ESO-1-based Immunotherapy of Myeloma Determination of Osteoprogenitor-specific Promoter Activity in Mouse Mesenchymal Stem Cells by Recombinant Adeno-associated Virus Transduction Recombinant Adeno-associated Virus 2-mediated Antiangiogenic Prevention in a Mouse Model of Intraperitoneal Ovarian Cancer Adeno-associated Virus 2-mediated Antiangiogenic Cancer Gene Therapy: Long-term Efficacy of a Vector Encoding Angiostatin and Endostatin over Vectors Encoding a Single Factor Conjugate-based Targeting of Recombinant Adeno-associated Virus Type 2 Vectors by Using Avidin-linked Ligands   Siegal, Gene, M.D., Ph.D. Research Focus: Gene therapy of solid tumors Select Highlights and Articles: UAB Center for Musculoskeletal Oncology: Offering New Hope for Soft Tissue and Bony Tumors Osteoarcoma: Anatomic and Histologic Variants Preclinical Evaluation of Transcriptional Targeting Strategies for Carcinoma of the Breast in a Tissue Slice Model System Desmoplastic Fibroma of the Jaw: A Case Report and Review of Literature Loss of Fibroblast Thy-1 Expression Correlates with Lung Fibrogenesis Fluorescently Tagged Canine Adenovirus Via Modification with Protein IX-enhanced Green Fluorescent Protein A Fiber-Modified, Secretory Leukoprotease Inhibitor Promoter-based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

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