Cell Matrix: Cell Matrix

AIDS | Bone | Cancer | Cardiovascular | Cell Matrix | Gene Therapy Immunology | Infectious Disease | Metabolic Disease | Neurobiology

Research is centered on extracellular matrix control of normal and cancerous cell movement and growth.   Cell adhesion and migration are involved in the development and function of almost every organ, and are essential for blood pressure maintenance, bone remodeling, nerve network building, and tumor metastasis. Typical student projects investigate the mechanisms involved in abnormal adhesion and migration that contribute to pathological states of different diseases.

UAB Cell Adhesion and Matrix Research Center (CAMRC) CAMRC: Unraveling the Complexities of Tissue Fibrosis CAMRC Expands Translational Possibilities: FRET Microscopy Core Facility  UAB Arthritis and Musculoskeletal Center UAB Receives Brain Tumor SPORE: $11.5 Million Grant to Develop New Therapies

Molecular & Cellular Pathology Cell Matrix Research Faculty   Gladson, Candece, M.D. Research Focus: Malignant astrocytoma cell migration Select Highlights and Articles: UAB Receives Brain Tumor SPORE: $11.5 Million Grant to Develop New Therapies Syndecan-2 Is Expressed in the Microvasculature of Gliomas and Regulates Angiogenic Processes in Microvascular Endothelial Cells A Novel Technique to Quantify Glioma Tumor Invasion Using Serial Microscopy Sections Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors Lyn Kinase Activity Is the Predominant Cellular Src Kinase Activity in Glioblastoma Tumor Cells Endogenous Inhibitors of Angiogenesis in Malignant Gliomas: Nature's Antiangiogenic Therapy   Kucik, Dennis, M.D., Ph.D. Research Focus: Cell adhesion and motility Select Highlights and Articles: Both Th1 and Th2 Cells Require P-selectin Glycoprotein Ligand-1 for Optimal Rolling on Inflamed Endothelium Revealing Anti-inflammatory Mechanisms of Soy Isoflavones by Flow: Modulation of Leukocyte-Endothelial Cell Interactions Intercellular Adhesion Molecule-1 (ICAM-1) Regulates Endothelial Cell Motility through a Nitric Oxide-dependent Pathway Avidity Modulation Activates Adhesion under Flow and Requires Cooperativity among Adhesion Receptors Thrombospondin Signaling through the Calreticulin/LDL Receptor-related Protein Co-complex Stimulates Random and Directed Cell Migration   Murphy-Ullrich, Joanne, Ph.D. Research Focus: Regulation of cell death and motility by cell adhesion signaling and role of growth factor control in diabetic and fibrotic diseases Select Highlights and Articles: Cell Adhesion and Matrix Research Center: Unraveling the Complexities of Tissue Fibrosis CAMRC Expands Translational Possibilities: FRET Microscopy Core Facility Launched  Thrombospondin I Mediates Angiotensin II Induction of TGF-Beta Activation by Cardiac and Renal Cells under Both High and Low Glucose Conditions Glutathione Restores Collagen Degradation in TGF-Beta-treated Fibroblasts by Blocking Plasminogen Activator Inhibiitor-1 Expression and Activating Plasminogen Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte Endothelin-A Receptor Blockade Prevents and Partially Reverses Neonatal Hypoxic Pulmonary Vascular Remodeling Transducible Heat Shock Protein 20 (HSP20) Phosphopeptide Alters Cytoskeletal Dynamics

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